Both YAP1-MAML2 and constitutively active YAP1 drive the formation of tumors that resemble NF2-mutant meningiomas in mice
F. Szulzewsky, S. Arora, A. Arakaki, P. Sievers, D. A. A. Bonnin, P. J. Paddison, F. Sahm, P. J. Cimino, T. Gujral, E. C. Holland
This study shows that YAP1-MAML2 and active YAP1 drive tumors resembling NF2-mutant meningiomas in mice through TEAD-dependent YAP activity.
bioRxiv · May 2, 2022 · PreprintCancer Biology