F. Szulzewsky

ERK signaling promotes resistance to TRK kinase inhibition in NTRK fusion-driven glioma mouse models.

This study shows ERK signaling promotes resistance to TRK inhibitors in NTRK fusion-driven glioma mouse models and suggests MEK inhibition as a potential combination therapy.

RNA Polymerase II hypertranscription at histone genes in cancer FFPE samples

The paper identifies RNA Polymerase II hypertranscription at histone genes in cancer FFPE samples, linking it to tumor progression and aneuploidy.

Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome.

This study combines bulk RNA-Seq datasets to create a transcriptomic landscape of meningiomas, identifies subtypes with distinct biology and prognosis, and provides an interactive tool for outcome prediction.

Epigenomic analysis of Formalin-Fixed Paraffin-Embedded samples by CUT&Tag

This study modifies the CUTAC protocol to enable high-resolution epigenomic analysis of FFPE samples, identifying regulatory element differences in mouse brain tumors.

Both YAP1-MAML2 and constitutively active YAP1 drive the formation of tumors that resemble NF2-mutant meningiomas in mice

This study shows that YAP1-MAML2 and active YAP1 drive tumors resembling NF2-mutant meningiomas in mice through TEAD-dependent YAP activity.

A paracrine circuit of IL-1b/IL-1R1 between myeloid and tumor cells drives glioblastoma progression

The paper identifies a paracrine IL-1β/IL-1R1 circuit between myeloid and tumor cells that drives glioblastoma progression and shows that antagonizing this circuit reduces tumor growth and extends survival.

Oncogenic role of a developmentally regulated NTRK2 splice variant

The paper identifies TrkB.T1, an embryonic NTRK2 splice variant, as an oncogenic driver in multiple tumor types across species, with distinct interactors in developmental and oncogenic pathways.