Author

E. C. Holland

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 8 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:mouse· 7 Research Focus:cancer & tumor microenvironment· 5 Organism:human· 5 Research Focus:gene regulatory network inference· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3

Frequent Co-Authors

F. Szulzewsky· 6 shared P. J. Cimino· 4 shared S. Arora· 3 shared Z. R. Russell· 3 shared F. Sahm· 2 shared H. N. Thirimanne· 2 shared J. G. Henikoff· 2 shared J. Shendure· 2 shared

Activity by Year

2021-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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6 shared papersCancer Biology

F. Szulzewsky

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

All-trans retinoic acid induces durable tumor immunity in IDH-mutant gliomas by rescuing transcriptional repression of the CRBP1-retinoic acid axis

A. Rao, X. Zhang, A. Cillo, J. H. Sussman, P. Sandlesh, A. C. Tarbay, A. N. Mallela, C. Cardello, K. Krueger, J. Xu, A. Li, J. Xu, J. Patterson, E. Akca, A. Angione, , N. M. Amankulor

This study shows that all-trans retinoic acid (ATRA) improves immune response in IDH-mutant gliomas by restoring the RA pathway, leading to tumor regression in mouse models and a clinical trial for human patients.

bioRxiv · Apr 9, 2024 · PreprintCancer Biology

ERK signaling promotes resistance to TRK kinase inhibition in NTRK fusion-driven glioma mouse models.

S. Schmid, Z. R. Russell, A. S. Yamashita, M. E. West, A. G. Parrish, J. Walker, D. Rudoy, J. Z. Yan, D. C. Quist, B. N. Gessesse, N. Alvinez, P. J. Cimino, D. K. Kumasaka, R. E. Parchment, E. C. Holland, F. Szulzewsky

This study shows ERK signaling promotes resistance to TRK inhibitors in NTRK fusion-driven glioma mouse models and suggests MEK inhibition as a potential combination therapy.

bioRxiv · Mar 13, 2024Cancer Biology

RNA Polymerase II hypertranscription at histone genes in cancer FFPE samples

S. Henikoff, Y. Zheng, R. M. Paranal, Y. Xu, J. E. Greene, J. G. Henikoff, Z. R. Russell, F. Szulzewsky, H. N. Thirimanne, S. Kugel, E. C. Holland, K. Ahmad

The paper identifies RNA Polymerase II hypertranscription at histone genes in cancer FFPE samples, linking it to tumor progression and aneuploidy.

bioRxiv · Feb 28, 2024Cancer Biology

Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome.

H. N. Thirimanne, D. A. Bonnin, N. Nuechterlein, S. Arora, M. Jensen, C. A. Parada, C. Qiu, F. Szulzewsky, C. W. English, W. C. Chen, P. Sievers, F. Nassiri, J. Z. Wang, T. J. Klisch, K. D. Aldape, , E. C. Holland

This study combines bulk RNA-Seq datasets to create a transcriptomic landscape of meningiomas, identifies subtypes with distinct biology and prognosis, and provides an interactive tool for outcome prediction.

bioRxiv · Feb 23, 2024Cancer Biology

Rolling the evolutionary dice: Neisseria commensals as proxies for elucidating the underpinnings of antibiotic resistance mechanisms and evolution in human pathogens

K. M. Frost, S. L. Charron-Smith, T. C. Cotsonas, D. C. Dimartino, R. C. Eisenhart, E. T. Everingham, E. C. Holland, K. Imtiaz, C. J. Kornowicz, L. E. Lenhard, L. H. Lynch, N. P. Moore, K. Phadke, M. L. Reed, S. R. Smith, , C. B. Wadsworth

This study uses in vitro evolution of commensal Neisseria species to investigate resistance evolution to azithromycin and penicillin, finding convergent mutations in key resistance mechanisms.

bioRxiv · Sep 26, 2023 · PreprintMicrobiology

Epigenomic analysis of Formalin-Fixed Paraffin-Embedded samples by CUT&Tag

S. Henikoff, J. G. Henikoff, K. Ahmad, R. M. Paranal, D. H. Janssens, Z. R. Russell, F. Szulzewsky, S. Kugel, E. C. Holland

This study modifies the CUTAC protocol to enable high-resolution epigenomic analysis of FFPE samples, identifying regulatory element differences in mouse brain tumors.

bioRxiv · Jun 20, 2023Cancer Biology

Both YAP1-MAML2 and constitutively active YAP1 drive the formation of tumors that resemble NF2-mutant meningiomas in mice

F. Szulzewsky, S. Arora, A. Arakaki, P. Sievers, D. A. A. Bonnin, P. J. Paddison, F. Sahm, P. J. Cimino, T. Gujral, E. C. Holland

This study shows that YAP1-MAML2 and active YAP1 drive tumors resembling NF2-mutant meningiomas in mice through TEAD-dependent YAP activity.

bioRxiv · May 2, 2022 · PreprintCancer Biology

Oncogenic role of a developmentally regulated NTRK2 splice variant

S. S. Pattwell, S. Arora, N. Nuechterlein, M. Zager, K. R. Loeb, P. J. Cimino, N. C. Holland, N. Reche-Ley, H. Bolouri, D. A. A. Bonin, F. Szulzewsky, V. V. Phadnis, T. Ozawa, M. J. Wagner, M. C. Haffner, , E. C. Holland

The paper identifies TrkB.T1, an embryonic NTRK2 splice variant, as an oncogenic driver in multiple tumor types across species, with distinct interactors in developmental and oncogenic pathways.

bioRxiv · Jan 7, 2022 · PreprintCancer Biology

Single-cell RNA Sequencing Reveals Immunosuppressive Myeloid Cell Diversity and Restricted Cytotoxic Effector Cell Trafficking and Activation During Malignant Progression in Glioma

S. Rajendran, C. Peterson, A. Canella, Y. Hu, A. Gross, M. Cam, A. Serin Harmanci, R. Distefano, G. Nigita, W. Wang, K. E. Miller, O. Elemento, R. D. Roberts, E. C. Holland, G. Rao, , P. Rajappa

This study uses single-cell RNA sequencing to analyze immune cell changes during glioma progression, identifying immunosuppressive myeloid cell subsets and potential therapeutic targets.

bioRxiv · Sep 24, 2021 · PreprintCancer Biology