Author

P. J. Paddison

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Assay:ChIP-seq· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

D. H. Janssens· 2 shared S. Arora· 2 shared S. Henikoff· 2 shared A. Arakaki· 1 shared A. Kashyap· 1 shared A. Lauko· 1 shared A. P. Patel· 1 shared B. E. Clurman· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersMicrobiology

D. H. Janssens

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency

E. Hsieh, D. H. Janssens, P. J. Paddison, E. P. Browne, S. Henikoff, M. Ohainle, M. Emerman

This study uses a CRISPR screen to identify pathways involved in HIV-1 latency, finding that ING3 and AZD5582 combination activates proviruses.

bioRxiv · Aug 23, 2022Microbiology

Both YAP1-MAML2 and constitutively active YAP1 drive the formation of tumors that resemble NF2-mutant meningiomas in mice

F. Szulzewsky, S. Arora, A. Arakaki, P. Sievers, D. A. A. Bonnin, P. J. Paddison, F. Sahm, P. J. Cimino, T. Gujral, E. C. Holland

This study shows that YAP1-MAML2 and active YAP1 drive tumors resembling NF2-mutant meningiomas in mice through TEAD-dependent YAP activity.

bioRxiv · May 2, 2022 · PreprintCancer Biology

Global and context-specific transcriptional consequences of oncogenic Fbw7 mutations

H. N. Thirmanne, F. Wu, D. H. Janssens, J. Swanger, H. Feldman, R. Amezquita, R. Gottardo, P. J. Paddison, S. Henikoff, B. E. Clurman

This study examines the transcriptional effects of Fbw7 mutations in colorectal cancer cells and identifies context-specific regulatory changes and co-regulated genes like CIITA.

bioRxiv · Oct 19, 2021Cancer Biology

WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma

K. Mitchell, S. Shakya, S. Arora, S. A. Sprowls, D. J. Silver, C. M. Goins, L. Wallace, G. Roversi, R. Schafer, K. Kay, T. E. Miller, A. Lauko, A. Kashyap, J. D. Kass, E. E. Mulkearns-Hubert, , J. D. Lathia

This study identifies WDR5 as an essential epigenetic regulator in therapy-resistant glioblastoma cancer stem cells and shows that WDR5 inhibitors disrupt CSC maintenance and tumor growth.

bioRxiv · Sep 20, 2021Cancer Biology