P. Sievers

Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome.

This study combines bulk RNA-Seq datasets to create a transcriptomic landscape of meningiomas, identifies subtypes with distinct biology and prognosis, and provides an interactive tool for outcome prediction.

The MTORC1-AHR pathway sustains translation and autophagy in tumours under tryptophan stress

This study identifies the MTORC1-AHR pathway as a mechanism sustaining translation and autophagy in tumors under tryptophan stress by enhancing AHR activity and autophagy regulators.

Both YAP1-MAML2 and constitutively active YAP1 drive the formation of tumors that resemble NF2-mutant meningiomas in mice

This study shows that YAP1-MAML2 and active YAP1 drive tumors resembling NF2-mutant meningiomas in mice through TEAD-dependent YAP activity.

A connectivity signature for glioblastoma

This paper establishes and validates a connectivity signature in glioblastoma using scRNA-Seq data, showing high connectivity correlates with poor patient survival and specific molecular subtypes.

Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial ependymoma

The paper identifies a novel subset of supratentorial ependymomas in children characterized by recurrent PLAGL1 fusions and distinct molecular features.

A subset of pediatric thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR

This study identifies a distinct subset of pediatric gliomas with EGFR alterations, H3K27me3 loss, and broad tumor localization, suggesting EGFR inhibition as a potential therapy.