Author

D. A. C. Heesterbeek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:E. coli· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 1

Frequent Co-Authors

B. W. Bardoel· 3 shared S. H. M. Rooijakkers· 3 shared M. Ruyken· 2 shared C. J. C. de Haas· 1 shared D. A. C. Stapels· 1 shared D. J. Doorduijn· 1 shared D. Y. Siere· 1 shared E. Dolk· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersImmunology

B. W. Bardoel

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3 papers

Recent·Most cited

Inhibition of cleavage of human complement component C5 and the R885H C5 variant by two distinct high affinity anti-C5 nanobodies

E. M. Struijf, K. I. De la O Becerra, M. Ruyken, F. van Oosterom, D. Y. Siere, D. A. C. Heesterbeek, E. Dolk, R. Heukers, B. W. Bardoel, P. Gros, S. H. M. Rooijakkers

This study identifies and characterizes two high-affinity anti-C5 nanobodies that inhibit C5 cleavage and recognize distinct epitopes, including a variant not targeted by Eculizumab.

bioRxiv · Feb 22, 2023Immunology

Polymerization of C9 enhances bacterial cell envelope damage and killing by membrane attack complex pores

D. J. Doorduijn, D. A. C. Heesterbeek, M. Ruyken, C. J. C. de Haas, D. A. C. Stapels, P. C. Aerts, S. H. M. Rooijakkers, B. W. Bardoel

This study shows that C9 polymerization enhances MAC pore-mediated bacterial killing and is impaired in complement-resistant strains.

bioRxiv · May 12, 2021Microbiology

Outer membrane permeabilization by the membrane attack complex sensitizes Gram-negative bacteria to antimicrobial proteins in serum and phagocytes

D. A. C. Heesterbeek, R. M. Muts, V. P. van Hensbergen, P. de Saint Aulaire, T. Wennekes, B. W. Bardoel, N. M. van Sorge, S. H. M. Rooijakkers

This study shows how MAC pores in Gram-negative bacteria's outer membrane make them more susceptible to immune system components like lysozyme and phospholipases, enhancing bacterial clearance.

bioRxiv · Jan 28, 2020Immunology