Author

P. C. Aerts

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:human· 3 Assay:proteomics· 3 Research Focus:differential expression· 1 Organism:E. coli· 1 Assay:metagenomics· 1 Organism:mouse· 1

Frequent Co-Authors

C. J. C. de Haas· 2 shared J. A. van Strijp· 2 shared S. H. M. Rooijakkers· 2 shared S. H. Rooijakkers· 2 shared A. C. Fluit· 1 shared A. E. H. Bentlage· 1 shared A. Hendriks· 1 shared A. Lux· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersMicrobiology

C. J. C. de Haas

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Author profile →

5 papers

Recent·Most cited

Glycan-specific IgM is critical for human immunity to Staphylococcus aureus

A. Hendriks, P. F. Kerkman, M. R. Varkila, J. L. Haitsma-Mulier, S. Ali, T. ten Doesschate, T. W. van der Vaart, C. J. C. de Haas, P. C. Aerts, O. L. Cremer, M. J. Bonten, V. Nizet, G. Y. Liu, J. D. C. Codee, S. H. Rooijakkers, , N. M. van Sorge

This study identifies WTA-specific IgM as a critical immune factor for human protection against S. aureus, outperforming IgG in opsonophagocytic activity and correlating with clinical outcomes.

bioRxiv · Jul 14, 2023 · PreprintMicrobiology

Growth inhibition of Akkermansia muciniphila by a secreted pathobiont sialidase

G. H. van Muijlwijk, E. Bröring, G. van Mierlo, P. W. Jansen, M. Vermeulen, P. C. Aerts, J. P. van Putten, N. W. Palm, M. R. de Zoete

The paper identifies a secreted sialidase from Allobaculum that inhibits Akkermansia muciniphila growth by altering its glycometabolic niche.

bioRxiv · Mar 15, 2022 · PreprintMicrobiology

Staphylococcal protein A inhibits IgG-mediated phagocytosis by blocking the interaction of IgGs with FcγRs and FcRn

A. R. Cruz, A. E. H. Bentlage, R. Blonk, C. J. C. d. Haas, P. C. Aerts, L. M. Scheepmaker, I. G. Bouwmeester, A. Lux, J. A. G. v. Strijp, F. Nimmerjahn, K. P. M. v. Kessel, G. Vidarsson, S. H. M. Rooijakkers

bioRxiv · Jan 21, 2022 · PreprintMicrobiology

Polymerization of C9 enhances bacterial cell envelope damage and killing by membrane attack complex pores

D. J. Doorduijn, D. A. C. Heesterbeek, M. Ruyken, C. J. C. de Haas, D. A. C. Stapels, P. C. Aerts, S. H. M. Rooijakkers, B. W. Bardoel

This study shows that C9 polymerization enhances MAC pore-mediated bacterial killing and is impaired in complement-resistant strains.

bioRxiv · May 12, 2021Microbiology

Human monoclonal antibodies against Staphylococcus aureus surface antigens recognize in vitro biofilm and in vivo implant infections

L. de Vor, B. van Dijk, K. P. van Kessel, J. S. Kavanaugh, C. J. de Haas, P. C. Aerts, M. C. Viveen, E. C. Boel, A. C. Fluit, J. M. Kwiecinski, G. C. Krijger, R. M. Ramakers, F. J. Beekman, E. Dadachova, M. G. Lam, , S. H. Rooijakkers

The paper identifies human monoclonal antibodies that recognize Staphylococcus aureus biofilms in vitro and in vivo, with some specifically targeting biofilm-associated antigens.

bioRxiv · Feb 9, 2021 · PreprintMicrobiology