Author

D. B. Wilburn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Assay:protein structure· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

L. M. Tuttle· 3 shared R. E. Klevit· 3 shared W. J. Swanson· 2 shared A. Zelter· 1 shared B. C. Searle· 1 shared C. L. Kunkel· 1 shared K. E. Kermoade· 1 shared M. Wang· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersBiochemistry

L. M. Tuttle

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

BRCA1/BARD1 intrinsically disordered regions facilitate chromatin recruitment and ubiquitylation.

S. R. Witus, L. M. Tuttle, W. Li, A. Zelter, M. Wang, K. E. Kermoade, D. B. Wilburn, T. N. Davis, P. Brzovic, W. Zhao, R. E. Klevit

This study identifies intrinsically disordered regions in BRCA1/BARD1 that mediate chromatin recruitment and ubiquitylation, enhancing DNA damage repair and transcriptional regulation.

bioRxiv · Aug 9, 2022Biochemistry

Recurrent co-option and recombination of cytokine and three finger proteins in multiple reproductive tissues throughout salamander evolution

D. B. Wilburn, C. L. Kunkel, R. C. Feldhoff, P. W. Feldhoff, B. C. Searle

This study characterizes salamander gametes using transcriptomics and proteomics, revealing recurrent co-option and recombination of cytokine and three-finger proteins in reproductive tissues across evolution.

bioRxiv · Jan 4, 2022Evolutionary Biology

Indirect sexual selection drives rapid sperm protein evolution

D. B. Wilburn, L. M. Tuttle, R. E. Klevit, W. J. Swanson

The paper shows that FITZAP, a sperm protein in abalone, coevolves with lysin to maintain binding despite rapid changes in the lysin-VERL interface, driven by sexual selection.

bioRxiv · Jul 29, 2019Biochemistry

Solution structure of sperm lysin yields novel insights into molecular dynamics of rapid protein evolution

D. B. Wilburn, L. M. Tuttle, R. E. Klevit, W. J. Swanson

This study presents the solution structure of sperm lysin from red abalone and identifies a VERL binding interface shaped by positive selection and structural flexibility.

bioRxiv · Jul 7, 2017Evolutionary Biology