T. N. Davis

BRCA1/BARD1 intrinsically disordered regions facilitate chromatin recruitment and ubiquitylation.

This study identifies intrinsically disordered regions in BRCA1/BARD1 that mediate chromatin recruitment and ubiquitylation, enhancing DNA damage repair and transcriptional regulation.

Discovery and visualization of uncharacterized drug-protein adducts using mass spectrometry.

The paper introduces Magnum, an algorithm for identifying drug-protein adducts, and Limelight, a tool for analyzing and visualizing adduct data, validated with CYP3A4 examples.

Microtubule associated proteins and motors required for ectopic microtubule array formation in S. cerevisiae

The paper identifies microtubule-associated proteins and motors essential for forming ectopic microtubule arrays in yeast by using a novel inducible nucleation site.

CM1-driven assembly and activation of Yeast γ-Tubulin Small Complex underlies microtubule nucleation

This study elucidates the role of the CM1 motif in Spc110p in facilitating γ-Tubulin Small Complex (γTuSC) assembly and γ-Tubulin Ring Complex (γTuRC) formation in yeast.

XMAP215 and γ-tubulin additively promote microtubule nucleation in purified solutions

This study investigates whether XMAP215 and γ-tubulin synergize in microtubule nucleation and finds they act additively, not synergistically, in purified solutions.

Novel phosphorylation states of the yeast spindle pole body

The paper reports a phosphoproteomic analysis of yeast spindle pole bodies (SPBs) under two cell cycle conditions, identifying novel phosphorylation sites on γ-TuSC that regulate microtubule nucleation and spindle length.

The human Ska complex and Ndc80 complex interact to form a load-bearing assembly that strengthens kinetochore-microtubule attachments

This study shows the Ska complex directly strengthens kinetochore-microtubule attachments by forming a load-bearing connection with the Ndc80 complex and microtubule tips.