Author

L. M. Tuttle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:protein structure· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

D. B. Wilburn· 3 shared R. E. Klevit· 3 shared W. J. Swanson· 2 shared A. Zelter· 1 shared K. E. Kermoade· 1 shared M. Wang· 1 shared P. Brzovic· 1 shared S. R. Witus· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersBiochemistry

D. B. Wilburn

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Author profile →

3 papers

Recent·Most cited

BRCA1/BARD1 intrinsically disordered regions facilitate chromatin recruitment and ubiquitylation.

S. R. Witus, L. M. Tuttle, W. Li, A. Zelter, M. Wang, K. E. Kermoade, D. B. Wilburn, T. N. Davis, P. Brzovic, W. Zhao, R. E. Klevit

This study identifies intrinsically disordered regions in BRCA1/BARD1 that mediate chromatin recruitment and ubiquitylation, enhancing DNA damage repair and transcriptional regulation.

bioRxiv · Aug 9, 2022Biochemistry

Indirect sexual selection drives rapid sperm protein evolution

D. B. Wilburn, L. M. Tuttle, R. E. Klevit, W. J. Swanson

The paper shows that FITZAP, a sperm protein in abalone, coevolves with lysin to maintain binding despite rapid changes in the lysin-VERL interface, driven by sexual selection.

bioRxiv · Jul 29, 2019Biochemistry

Solution structure of sperm lysin yields novel insights into molecular dynamics of rapid protein evolution

D. B. Wilburn, L. M. Tuttle, R. E. Klevit, W. J. Swanson

This study presents the solution structure of sperm lysin from red abalone and identifies a VERL binding interface shaped by positive selection and structural flexibility.

bioRxiv · Jul 7, 2017Evolutionary Biology