Lipid Droplets Promote Phase Separation of Ago2 to Accelerate Dicer1 Loss and Decelerate miRNA Activity in Lipid Exposed Hepatic Cells
D. Bandopadhyay, S. Basu, I. Mukherjee, R. Chakraborty, K. Mukherjee, K. Chattopadhyay, S. Chakrabarti, P. Chakrabarti, S. N. Bhattacharyya
The paper shows lipid droplets promote Ago2 phase separation, reduce Dicer1 levels, and decrease miR-122 activity in hepatic cells under lipotoxic stress.
bioRxiv · Nov 30, 2020 · PreprintCell Biology