S. N. Bhattacharyya

RNA Binding of Syntaxin 5 Synergises Membrane Fusion to Accelerate miRNA Export and Clear Pathogens

This paper identifies Syntaxin5's role in miRNA export and pathogen clearance by showing its RNA-binding and SNARE domain functions in macrophages.

HuR-miRNA complex Activates RAS GTPase RalA to Facilitate Endosome Targeting and Extracellular Export of miRNAs

The paper develops an in vitro assay to study miRNA packaging into endosomes and shows that HuR-miRNA complexes activate RalA GTPase to facilitate miRNA import and export.

Leishmania Hijacks microRNA Import-Export Machinery of Infected Macrophage and Survives by Cross-Communicating Host miR-146a to Subjugate HuR and miR-122 in Neighbouring cells

This study shows Leishmania manipulates host miRNA transport to suppress inflammation and promote its survival by exporting miR-146a and inhibiting miR-122 in neighboring cells.

Inhibition of Extracellular Vesicle-Associated MMP2 Abrogates Intercellular Transfer of Hepatic miR-122 to Tissue Macrophages and Curtails Liver Inflammation

The paper shows that inhibiting MMP2 on extracellular vesicles reduces miR-122 transfer to macrophages, thereby decreasing liver inflammation.

Amyloid Beta Oligomers Prevents Lysosomal Targeting of miRNP to Stop Its Recycling and Target Cytokine Repression in Glial Cells

The paper shows amyloid beta oligomers prevent miRNP lysosomal targeting, leading to cytokine repression failure in glial cells.

Lipid Droplets Promote Phase Separation of Ago2 to Accelerate Dicer1 Loss and Decelerate miRNA Activity in Lipid Exposed Hepatic Cells

The paper shows lipid droplets promote Ago2 phase separation, reduce Dicer1 levels, and decrease miR-122 activity in hepatic cells under lipotoxic stress.

Non-Canonical Ago Loading of EV-Derived Exogenous miRNA Generates Foreign miRNPs on Endosomes to Arbitrate Gene Expression in Recipient Cells

The paper shows EV-derived miRNAs are loaded onto host Ago proteins on endosomes without Dicer1, using mitochondrial activity, to regulate gene expression in recipient cells.