K. Chattopadhyay

Zn-dependent structural transition of SOD1 modulates its ability to undergo liquid-liquid phase separation.

This study shows that Zn-dependent structural changes in SOD1 affect its ability to undergo liquid-liquid phase separation, which may contribute to ALS pathology.

In vitro reconstitution demonstrates the amyloid-beta mediated myelin membrane deformation

This study shows A{beta}-40 induces myelin membrane tubulation in vitro through binding and aggregation, revealing mechanisms of potential neuronal demyelination in Alzheimer's Disease.

The metal cofactor zinc and interacting membranes modulate SOD1 conformation-aggregation landscape in an in vitro ALS Model

This study shows that Zn absence, not Cu, affects SOD1 membrane attachment and aggregation in an ALS model, linking it to disease progression.

Lipid Droplets Promote Phase Separation of Ago2 to Accelerate Dicer1 Loss and Decelerate miRNA Activity in Lipid Exposed Hepatic Cells

The paper shows lipid droplets promote Ago2 phase separation, reduce Dicer1 levels, and decrease miR-122 activity in hepatic cells under lipotoxic stress.

Membrane composition and lipid to protein ratio modulate amyloid kinetics of yeast prion protein

The paper investigates how membrane composition and lipid-to-protein ratio affect the aggregation kinetics of yeast prion protein Sup35, finding biphasic aggregation at optimal lipid concentrations.

An exploration of the SARS-CoV-2 spike receptor binding domain (RBD), a complex palette of evolutionary and structural features

The paper analyzes the SARS-CoV-2 spike RBD using evolutionary and structural methods to identify potential druggable regions.

Protein induced membrane phase transition facilitates leishmania infection

This study shows that the Leishmania Donovani protein KMP-11 induces membrane phase transition in macrophages, facilitating infection by altering membrane tension and lipid raft structure.

Identification of QTLs for high grain yield and component traits in New Plant Types of rice

The paper identifies QTLs associated with grain yield and related traits in rice using SSR markers and association analysis.

Heme minimizes Parkinson’s disease-associated toxicity by inducing a conformational distortion in the oligomers of alpha-Synuclein

This study shows heme reduces alpha-Synuclein toxicity by altering its oligomer structure, preventing harmful fibril formation.

Electron microscopy reveals unique spore-like nano forms of Bacillus cereus

The paper uses electron microscopy to identify nano-spore-like structures in Bacillus cereus under stress, showing they can bypass sterile filtration and transform into mature cells upon nutrient supply.

Small Molecules Attenuate the Interplay between Conformational Fluctuations, Early Oligomerization and Amyloidosis of Alpha Synuclein

The paper investigates how small molecules affect the conformational dynamics and aggregation of alpha synuclein, showing additive effects of an inhibitor and facilitator on different stages of aggregation.