Author

D. Chmielewski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 4 Approach:experimental assay· 3 Research Focus:protein structure prediction· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:microscopy & imaging analysis· 2 Organism:virus· 2 Approach:deep learning· 1

Frequent Co-Authors

J. Jin· 4 shared W. Chiu· 4 shared G. Simmons· 2 shared K. Zhang· 2 shared M. F. Schmid· 2 shared A. J. Auguste· 1 shared D. Luo· 1 shared G. Pintilie· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersMicrobiology

J. Jin

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Author profile →

4 papers

Recent·Most cited

Molecular Architecture of the Chikungunya Virus Replication Complex

Y. B. Tan, D. Chmielewski, M. C. Y. Law, K. Zhang, Y. He, M. Chen, J. Jin, D. Luo, W. Chiu

This study determines the structure of the chikungunya virus replication complex at near-atomic and subnanometer resolution, revealing its molecular architecture and implications for antiviral therapy.

bioRxiv · Apr 8, 2022Microbiology

In situ Alphavirus Assembly and Budding Mechanism Revealed by Cellular CryoET

D. Chmielewski, M. F. Schmid, G. Simmons, J. Jin, W. Chiu

This study uses cryoET to reveal the in situ assembly and budding mechanism of CHIKV, showing spike-driven particle formation and NAb inhibition of spike-spike interactions.

bioRxiv · Oct 14, 2021 · PreprintMicrobiology

Near-atomic resolution Cryo-EM structure of Mayaro virus identifies key structural determinants of alphavirus particle formation

D. Chmielewski, J. Kaelber, J. Jin, S. C. Weaver, A. J. Auguste, W. Chiu

The paper presents a near-atomic resolution cryo-EM structure of Mayaro virus, revealing structural determinants of alphavirus particle formation and identifying key residues involved in assembly.

bioRxiv · Jan 14, 2021 · PreprintMicrobiology

A 3.4-A cryo-EM structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particles

K. Zhang, S. Li, G. Pintilie, D. Chmielewski, M. F. Schmid, G. Simmons, J. Jin, W. Chiu

The paper presents a 3.4-A cryo-EM structure of the human coronavirus NL63 spike trimer from vitrified virus particles, revealing structural differences from SARS-CoV-2.

bioRxiv · Aug 11, 2020Biophysics