Author

G. Pintilie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 5 Research Focus:protein structure prediction· 4 Approach:experimental assay· 3 Organism:human· 3 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

W. Chiu· 5 shared K. Zhang· 3 shared S. Li· 3 shared M. F. Schmid· 2 shared Z. Su· 2 shared A. Leitner· 1 shared A. M. Watkins· 1 shared A. S. Powers· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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5 shared papersBiophysics

W. Chiu

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5 papers

Recent·Most cited

CryoEM structures of the human CLC-2 voltage gated chloride channel reveal a ball and chain gating mechanism

M. Xu, T. Neelands, A. S. Powers, Y. Liu, S. D. Miller, G. Pintilie, J. Du Bois, R. O. Dror, W. Chiu, M. Maduke

The paper reports cryoEM structures of human CLC-2 chloride channels, revealing a ball-and-chain gating mechanism involving an N-terminal hairpin peptide.

bioRxiv · Aug 13, 2023Biophysics

Structural visualization of the tubulin folding pathway directed by eukaryotic chaperonin TRiC

D. R. Gestaut, Y. Zhao, J. Park, B. Ma, A. Leitner, M. Collier, G. Pintilie, S. H. Roh, W. Chiu, J. Frydman

The paper visualizes the tubulin folding pathway mediated by TRiC using cryoEM, showing how TRiC's structure guides the folding of β-tubulin through specific interactions.

bioRxiv · Mar 25, 2022 · PreprintBiochemistry

A 3.4-A cryo-EM structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particles

K. Zhang, S. Li, G. Pintilie, D. Chmielewski, M. F. Schmid, G. Simmons, J. Jin, W. Chiu

The paper presents a 3.4-A cryo-EM structure of the human coronavirus NL63 spike trimer from vitrified virus particles, revealing structural differences from SARS-CoV-2.

bioRxiv · Aug 11, 2020Biophysics

Measurement of Atom Resolvability in CryoEM Maps with Q-scores

G. Pintilie, K. Zhang, Z. Su, S. Li, M. F. Schmid, W. Chiu

The paper introduces Q-scores to quantify atom resolvability in cryoEM maps and validates their reproducibility across different labs.

bioRxiv · Aug 5, 2019Biochemistry

Ribosolve: Rapid determination of three-dimensional RNA-only structures

K. Kappel, K. Zhang, Z. Su, W. Kladwang, S. Li, G. Pintilie, V. V. Topkar, R. Rangan, I. N. Zheludev, A. M. Watkins, J. D. Yesselman, W. Chiu, R. Das

Ribosolve rapidly determines 3D RNA-only structures using cryo-EM, chemical mapping, and Rosetta modeling, validated by multiple benchmarks and showing high accuracy.

bioRxiv · Jul 31, 2019Biophysics