M. F. Schmid

Dramatic Changes in Mitochondrial Subcellular Location and Morphology Accompany Activation of the CO2 Concentrating Mechanism

This study shows that mitochondrial repositioning and reorientation in Chlamydomonas reinhardtii under low CO2 conditions is regulated by CIA5 and supports CO2 concentrating mechanism function.

Cost-benefit analysis of cryogenic electron tomography subtomogram averaging of chaperonin MmCpn at near atomic resolution.

This study analyzes the factors affecting resolution in cryoET-STA for MmCpn, evaluating the cost-benefit of achieving high-resolution structures.

Structure of the Thin Filament in Human iPSC-derived Cardiomyocytes and its Response to Heart Disease

This study uses cryo-ET to analyze the structure of thin filaments in human iPSC-derived cardiomyocytes and how they change with disease-related perturbations.

Cryogenic electron tomography reveals novel structures in the apical complex of Plasmodium falciparum

This study uses cryogenic electron tomography to reveal new structural details of the apical complex in Plasmodium falciparum merozoites, including interactions between rhoptries and other structures.

In situ Alphavirus Assembly and Budding Mechanism Revealed by Cellular CryoET

This study uses cryoET to reveal the in situ assembly and budding mechanism of CHIKV, showing spike-driven particle formation and NAb inhibition of spike-spike interactions.

Resolving Individual-Atom of Protein Complex using Commonly Available 300-kV Cryo-electron Microscopes

The paper demonstrates near-atomic resolution structure determination of apoferritin using single-particle cryo-EM with a 300-kV Titan Krios microscope, achieving 1.35 Å resolution and resolving heavy atoms and rotameric configurations.

A 3.4-A cryo-EM structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particles

The paper presents a 3.4-A cryo-EM structure of the human coronavirus NL63 spike trimer from vitrified virus particles, revealing structural differences from SARS-CoV-2.

Outcomes of the 2019 EMDataResource model challenge: validation of cryo-EM models at near-atomic resolution

The paper evaluates cryo-EM model quality using benchmark maps, showing high accuracy and reproducibility across 13 teams and recommending multiple metrics for model assessment.

Measurement of Atom Resolvability in CryoEM Maps with Q-scores

The paper introduces Q-scores to quantify atom resolvability in cryoEM maps and validates their reproducibility across different labs.

Defining the Layers of a Sensory Cilium with STORM and Cryo-Electron Nanoscopies

The paper uses advanced microscopy techniques to define substructures within sensory cilia and examines the effects of ciliopathy proteins on protein distribution.