Author

N. Agrawal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cancer Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 4 Organism:human· 3 Approach:mechanistic / dynamical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

E. Parisini· 3 shared A. A. Skelton· 1 shared A. Gianni· 1 shared A. Liu· 1 shared A. Morrone· 1 shared A. Sacconi· 1 shared A. Srisuwananukorn· 1 shared A. T. Pearson· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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3 shared papersBiochemistry

E. Parisini

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Investigating the effect of POPC-POPG Lipid Bilayer Composition on PAP248-286 Binding using CG Molecular Dynamics Simulations

N. Agrawal, E. Parisini

This study uses CG molecular dynamics simulations to show that PAP248-286 binds more strongly to lipid bilayers with higher POPG content, especially when charged histidine residues are present.

bioRxiv · Jul 20, 2023Biochemistry

Detergent induced structural perturbations in peanut agglutinin: Insights from spectroscopic and molecular dynamic simulation studies

S. Asthana, S. Mohanty, H. Kalra, N. Karunanethi, S. Kumar, N. Agrawal, S. Jha

This study investigates how SDS and CTAB detergents affect the structure of peanut agglutinin using spectroscopic and molecular dynamics simulations, revealing structural perturbations and conformational changes.

bioRxiv · Jul 3, 2023Biochemistry

A Coarse-Grained Molecular Dynamics Investigation on Spontaneous Binding of Aβ1-40 Fibrils with Cholesterol-mixed DPPC Bilayers

N. Agrawal, A. A. Skelton, E. Parisini

This study uses molecular dynamics simulations to investigate how Aβ1-40 fibrils bind to cholesterol-containing DPPC bilayers, identifying key hydrophobic residues and a lysine involved in membrane interaction.

bioRxiv · Sep 16, 2022 · PreprintBiochemistry

Early Stages of Misfolding of PAP248-286 at two different pH values: An Insight from Molecular Dynamics Simulations

N. Agrawal, E. Parisini

This study uses molecular dynamics simulations to analyze the early misfolding stages of PAP248-286 peptide at two pH values, revealing structural and energetic differences that may inform HIV drug discovery.

bioRxiv · Jun 1, 2022Biochemistry

TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients.

A. Sacconi, S. Donzelli, C. Pulito, S. Ferrero, A. Morrone, M. Rigoni, F. Pimipinelli, F. Ensoli, G. Sanguineti, R. Pellini, N. Agrawal, E. Izumchenko, G. Ciliberto, A. Gianni, P. Muti, , G. Blandino

This study finds that TMPRSS2 expression is reduced in head and neck cancer tissues compared to normal tissues and is associated with poorer prognosis.

bioRxiv · Jun 16, 2020Cancer Biology

Functional interactions between post-translationally modified amino acids of methyl-coenzyme M reductase in Methanosarcina acetivorans

D. D. Nayak, A. Liu, N. Agrawal, R. Rodriguez-Carerro, S.-H. Dong, D. A. Mitchell, S. K. Nair, W. W. Metcalf

The paper identifies a methyltransferase responsible for S-methylcysteine modification in MCR and shows that interactions between post-translational modifications affect enzyme function and thermal stability.

bioRxiv · Sep 16, 2019Microbiology

Deep learning detects virus presence in cancer histology

J. N. Kather, J. Schulte, H. I. Grabsch, C. Loeffler, H. S. Muti, J. Dolezal, A. Srisuwananukorn, N. Agrawal, S. Kochanny, S. von Stillfried, P. Boor, T. Yoshikawa, D. Jaeger, C. Trautwein, P. Bankhead, , A. T. Pearson

This paper uses deep learning to detect the presence of HPV and EBV in cancer histology images, achieving high accuracy in predicting virus-associated tumors.

bioRxiv · Jul 5, 2019 · PreprintCancer Biology