S. K. Nair

Meta-analysis of preclinical pharmacogenomic studies to discover robust and translatable biomarkers of drug response

This study identifies 4,338 statistically significant biomarkers of drug response across 8 tissue types and 34 drugs using meta-analysis of preclinical pharmacogenomic studies, with ODC1 showing clinical relevance for Paclitaxel response in breast cancer.

Intratumor Childhood Vaccine-Specific CD4+ T cell Recall Coordinates Antitumor CD8+ T cells and Eosinophils

This paper shows that childhood vaccines can enhance antitumor immunity by coordinating CD4+ T cells, CD8+ T cells, and eosinophils in mouse models and correlates these effects with human transcriptome data.

Prevalence and mechanisms of evolutionary contingency in human influenza H3N2 neuraminidase

The paper identifies deleterious mutations in human influenza H3N2 neuraminidase and reveals epistatic networks shaping its evolution.

Nutrient limitation magnifies fitness costs of antimalarial drug resistance mutations

This study shows that fitness costs of antimalarial drug resistance mutations are significantly higher in nutrient-limited media compared to standard RPMI, suggesting underestimation in typical lab conditions.

Bimodality of gene expression in cancer patient tumors as interpretable biomarkers for drug sensitivity

The paper develops an interpretable machine learning pipeline to predict drug sensitivity in cancer cells using bimodal gene expression patterns from pharmacogenomic data.

Biochemical Basis for the Regulation of Biosynthesis of Antiparasitics by Bacterial Hormones

The paper describes a synthetic strategy for avenolide and characterizes its interaction with a receptor, identifying new actinobacteria regulated by butenolides.

Functional interactions between post-translationally modified amino acids of methyl-coenzyme M reductase in Methanosarcina acetivorans

The paper identifies a methyltransferase responsible for S-methylcysteine modification in MCR and shows that interactions between post-translational modifications affect enzyme function and thermal stability.