Author

J. A. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Biochemistry· 1 Bioengineering· 1 Cancer Biology· 1 Immunology· 1 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:bacteria (other)· 6 Assay:proteomics· 5 Research Focus:cell type annotation· 4 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3 Assay:metagenomics· 3 Approach:statistical model· 3

Frequent Co-Authors

C. J. Marx· 6 shared J. V. Bazurto· 2 shared L. B. Lambert· 2 shared T. Ticak· 2 shared A. Buchanan· 1 shared A. E. Vasdekis· 1 shared A. Govindaraju· 1 shared A. J. Tierny· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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6 shared papersMicrobiology

C. J. Marx

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Rapid spectrophotometric detection for optimized production of landomycins and characterization of their therapeutic potential

T. C. Chappell, K. G. Maiello, A. J. Tierny, K. Yanagi, J. A. Lee, K. Lee, C. R. Mace, C. S. Bennett, N. U. Nair

This study improves landomycin production in Streptomyces cyanogenus using spectrophotometric methods and characterizes their antimicrobial and anticancer activities.

bioRxiv · Nov 7, 2023Bioengineering

Agent-based Model for Microbial Populations Exposed to Radiation (AMMPER) simulates yeast growth for deep-space experiments

A. Singh, S. R. Santa Maria, D. M. Gentry, L. C. Liddell, M. P. Lera, J. A. Lee

AMMPER simulates the effects of proton radiation on yeast growth, reproducing growth rate changes but not lag time, and predicts future radiation responses.

bioRxiv · Oct 29, 2023Microbiology

Antibiotic persistence does not cause phenotypic heterogeneity in tolerance of Escherichia coli to formaldehyde stress but can preserve it through time

C. J. Marx, I. D. Jordan, T. Ticak, J. A. Lee

This study investigates whether antibiotic persistence causes phenotypic heterogeneity in Escherichia coli's tolerance to formaldehyde stress and finds that persistence can preserve tolerance over time but is not the cause of initial heterogeneity.

bioRxiv · Sep 23, 2022 · PreprintMicrobiology

Aerobic methoxydotrophy: growth on methoxylated aromatic compounds by Methylobacterium

J. A. Lee, S. Stolyar, C. J. Marx

This study identifies Methylobacterium strains capable of methoxydotrophy and aromatic ring metabolism, revealing their ecological relevance in lignin degradation and formaldehyde utilization.

bioRxiv · Jan 10, 2022Microbiology

Methylothon: a versatile course-based high school research experience in microbiology and bioinformatics-- with pink bacteria

P. A. Jones, D. Frischer, S. Mueller, T. Le, A. Schwanes, A. Govindaraju, K. E. Shalvarjian, J.-B. Leducq, C. J. Marx, N. C. Martinez-Gomez, J. A. Lee

Methylothon is a high school research module on microbiology and bioinformatics using pink bacteria, offering both in-person and remote versions with bioinformatics tools and community science participation.

bioRxiv · Sep 8, 2021Scientific Communication & Education

Myo-inositol Oxygenase Overexpression Rescues Vitamin C Deficient Arabidopsis (vtc) Mutants

L. M. Acosta-Gamboa, N. Nepal, K. Medina-Jimenez, Z. C. Campbell, S. S. Cunningham, J. A. Lee, A. Lorence

This study shows that overexpressing myo-inositol oxygenase (MIOX4) in Arabidopsis vtc mutants restores ascorbate levels, improves growth, and enhances abiotic stress tolerance.

bioRxiv · Feb 24, 2021 · PreprintBiochemistry

Formaldehyde-responsive proteins, TtmR and EfgA, reveal a tradeoff between formaldehyde resistance and efficient transition to methylotrophy in Methylorubrum extorquens

J. V. Bazurto, E. L. Bruger, J. A. Lee, L. B. Lambert, C. J. Marx

bioRxiv · Oct 19, 2020Microbiology

EfgA is a conserved formaldehyde sensor that halts bacterial translation in response to elevated formaldehyde

J. Bazurto, D. D. Nayak, T. Ticak, M. Davlieva, J. A. Lee, L. B. Lambert, O. J. Benski, C. J. Quates, J. L. Johnson, J. S. Patel, F. M. Ytreberg, Y. Shamoo, C. J. Marx

This study identifies EfgA as a formaldehyde sensor in Methylorubrum extorquens that inhibits translation under formaldehyde stress, without enzymatic detoxification.

bioRxiv · Oct 16, 2020Microbiology

Exploring Integrative Analysis using the BioMedical Evidence Graph

A. Struck, B. Walsh, A. Buchanan, J. A. Lee, R. Spangler, J. Stuart, K. Ellrott

The paper introduces the BioMedical Evidence Graph (BMEG), a graph database for integrative cancer biology analysis, demonstrating its utility through various queries and comparisons with other systems.

bioRxiv · Sep 25, 2019Cancer Biology

Microbial phenotypic heterogeneity in response to a metabolic toxin: continuous, dynamically shifting distribution of formaldehyde tolerance in Methylobacterium extorquens populations

J. A. Lee, S. Riazi, S. Nemati, J. V. Bazurto, A. E. Vasdekis, B. J. Ridenhour, C. H. Remien, C. J. Marx

The paper shows that Methylobacterium extorquens populations exhibit continuous, dynamic formaldehyde tolerance heterogeneity without genetic mutations.

bioRxiv · Sep 19, 2019Microbiology

PGE2 production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo

C. A. Loynes, J. A. Lee, A. L. Robertson, M. J. G. Steel, F. Ellett, Y. Feng, B. D. Levy, M. K. Whyte, S. A. Renshaw

This study shows that PGE2 promotes neutrophil reverse migration and anti-inflammatory signaling, aiding inflammation resolution in a zebrafish model.

bioRxiv · Dec 20, 2017Immunology