NETosis proceeds by cytoskeleton and endomembrane disassembly and PAD4-mediated chromatin de-condensation and nuclear envelope rupture
C. M. Waterman, H. R. Thiam, S. L. Wong, R. Qiu, M. Kittisopikul, A. V. Vahabikashi, A. E. Goldman, R. D. V. Goldman, D. D. Wagner
This study uses live-cell imaging to characterize the step-wise cellular events of NETosis in neutrophils and identifies PAD4's role in chromatin de-condensation and nuclear envelope rupture.
bioRxiv · Jun 6, 2019Immunology