D. Di Vizio

A Practical Approach for Targeting Structural Variants Genome-wide in Plasma Cell-free DNA

The paper introduces GAPF-seq, a method to detect structural variants in cfDNA, achieving high accuracy in distinguishing tumors from controls.

ONECUT2 Activates Diverse Resistance Drivers of Androgen Receptor-Independent Heterogeneity in Prostate Cancer

This study identifies ONECUT2 as a master transcription factor that drives resistance in prostate cancer through multiple mechanisms, including activation of neuroendocrine and adenocarcinoma variants, and shows that its inhibition can suppress treatment-resistant lineage plasticity.

Integrating extracellular vesicle and circulating cell-free DNA analysis on a single plasma aliquot from breast cancer patients improves the detection of HER2 positivity

This paper combines extracellular vesicle RNA and circulating cell-free DNA analysis from a single blood sample to improve HER2 positivity detection in breast cancer patients.

EV Fingerprinting: Resolving extracellular vesicle heterogeneity using multi-parametric flow cytometry

EV Fingerprinting uses flow cytometry to resolve EV heterogeneity and detect tumor-derived EVs in plasma.

Comprehensive palmitoyl-proteomic analysis identifies distinct protein signatures for large and small cancer-derived extracellular vesicles

This study identifies distinct palmitoyl-protein signatures in large and small cancer-derived extracellular vesicles using a novel proteomic approach.

Low-background Acyl-biotinyl Exchange Largely Eliminates the Co-isolation of Non-S-acylated Proteins and Enables Deep S-acylproteomic Analysis

The paper introduces a modified ABE method that reduces background noise in S-acylproteomic analysis, enabling the identification of 2,895 high-confidence S-acylated proteins in human prostate cancer cells.