K. Franze

Foreign body reaction is triggered in vivo by cellular mechanosensing of implants stiffer than host tissue

The paper shows that implants stiffer than host tissue trigger a foreign body reaction via mechanosensing, and soft coatings reduce inflammation and fibrosis.

Dynamic traction force measurements of migrating immune cells in 3D matrices

This study measures dynamic traction forces of migrating NK cells in 3D matrices and finds that force bursts increase with matrix stiffness to aid migration through constrictions.

EV Fingerprinting: Resolving extracellular vesicle heterogeneity using multi-parametric flow cytometry

EV Fingerprinting uses flow cytometry to resolve EV heterogeneity and detect tumor-derived EVs in plasma.

Brain tissue mechanics is governed by microscale relations of the tissue constituents

The paper develops a model to predict brain tissue mechanics by considering the non-affine deformations of individual constituents, showing that their assembly, not just stiffness, determines tissue properties.

Effective cell membrane tension is independent of polyacrylamide substrate stiffness

This study measures membrane tension in neurons and fibroblasts on different substrates, finding that effective membrane tension is independent of substrate stiffness and myosin II activity.

Unrestrained growth of correctly oriented microtubules instructs axonal microtubule orientation

The paper shows that +end out microtubules grow longer due to reduced catastrophe near the axon tip, leading to uniform microtubule orientation in neurons.

The Orsay Virus as a model for population-wide viral infection dynamics

This paper uses C. elegans infected with Orsay Virus to study population-wide viral infection dynamics, showing host genetics and behavior influence viral spread.

Robust T-cell signaling triggered on soft polydimethylsiloxane-supported lipid-bilayers

This study investigates T-cell signaling on soft lipid bilayers, finding early calcium signaling is not mechanosensitive but phosphatase exclusion occurs on soft substrates.

Cortical cell stiffness is independent of substrate mechanics

The paper shows that cortical cell stiffness is not affected by substrate mechanics after correcting for substrate deformation during AFM measurements.

Spatial heterogeneity of cell-matrix adhesive forces predicts human glioblastoma migration

This study shows that GBM cell migration is inversely correlated with cell-matrix adhesion strength and that 5-ALA fluorescence correlates with motility properties.

StemBond hydrogels optimise the mechanical microenvironment for embryonic stem cells

This study develops StemBond hydrogels that independently control substrate stiffness and ECM tethering, showing they enhance ES cell self-renewal and reprogramming efficiency.

KymoButler: A deep learning software for automated kymograph analysis

KymoButler automates kymograph analysis using deep learning, achieving performance comparable to manual expert analysis across diverse biological systems.

Predicting local tissue mechanics using immunohistochemistry

The paper develops a model to predict nervous tissue stiffness using immunohistochemical parameters and atomic force microscopy data.

Long-Term Imaging of Cellular Forces with High Precision by Elastic Resonator Interference Stress Microscopy

This paper introduces ERISM, a method to measure cellular forces with high precision and long-term imaging capabilities, enabling real-time analysis of mechanical interactions in cells.