Author

M. R. Freeman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Biochemistry· 1 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 7 Research Focus:cell type annotation· 4 Research Focus:cancer & tumor microenvironment· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2

Frequent Co-Authors

W. Yang· 4 shared B. Zhou· 3 shared C. Qian· 3 shared D. Di Vizio· 3 shared R. Murali· 3 shared S. You· 3 shared Y. Yan· 3 shared A. Chatterjee· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersCancer Biology

W. Yang

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Epigenetic disruption of the RARγ complex impairs its function to bookmark AR enhancer interactions required for enzalutamide sensitivity in prostate cancer

S. A. Wani, S. Hussain, J. S. Gray, D. Nayak, H. Tang, L. M. Perez, M. D. Long, M. Siddappa, C. McCabe, L. Campbell, M. R. Freeman, M. J. Campbell

This study identifies RARγ's role in bookmarking AR enhancer interactions in prostate cancer, showing its impact on enzalutamide sensitivity and lineage plasticity.

bioRxiv · Dec 15, 2023 · PreprintCancer Biology

ONECUT2 Activates Diverse Resistance Drivers of Androgen Receptor-Independent Heterogeneity in Prostate Cancer

C. Qian, Q. Yang, M. Rotinen, R. Huang, h. Kim, B. Gallent, Y. Yan, R. M. Cadaneanu, B. Zhang, S. Kaochar, S. J. Freedland, E. M. Posadas, L. Ellis, D. Di Vizio, C. Morrissey, , M. R. Freeman

This study identifies ONECUT2 as a master transcription factor that drives resistance in prostate cancer through multiple mechanisms, including activation of neuroendocrine and adenocarcinoma variants, and shows that its inhibition can suppress treatment-resistant lineage plasticity.

bioRxiv · Sep 28, 2023 · PreprintCancer Biology

The homeodomain drives favorable DNA binding energetics of prostate cancer target ONECUT2

A. Chatterjee, B. Gallent, M. Katiki, C. Qian, M. R. Harter, M. R. Freeman, R. Murali

This study shows the homeodomain stabilizes ONECUT2-DNA binding through allosteric modulation and conserved base interactions, with implications for prostate cancer.

bioRxiv · Jun 13, 2023Biophysics

RIPK2 Stabilizes c-Myc and is an Actionable Target for Inhibiting Prostate Cancer Metastasis

Y. Yan, B. Zhou, C. Qian, A. Vasquez, A. Chatterjee, X. Yuan, E. Posadas, N. Kyprianou, B. S. Knudsen, R. Murali, A. Gertych, S. You, M. R. Freeman, W. Yang

This study identifies RIPK2 as a target for inhibiting prostate cancer metastasis by stabilizing c-Myc and shows its suppression reduces disease progression.

bioRxiv · May 14, 2020Cancer Biology

Comprehensive palmitoyl-proteomic analysis identifies distinct protein signatures for large and small cancer-derived extracellular vesicles

J. Mariscal, T. Vagner, M. Kim, B. Zhou, A. Chin, M. Zandian, M. R. Freeman, S. You, A. Zijlstra, W. Yang, D. Di Vizio

This study identifies distinct palmitoyl-protein signatures in large and small cancer-derived extracellular vesicles using a novel proteomic approach.

bioRxiv · Oct 2, 2019Cancer Biology

Low-background Acyl-biotinyl Exchange Largely Eliminates the Co-isolation of Non-S-acylated Proteins and Enables Deep S-acylproteomic Analysis

B. Zhou, Y. Wang, Y. Yan, J. Mariscal, D. Di Vizio, M. R. Freeman, W. Yang

The paper introduces a modified ABE method that reduces background noise in S-acylproteomic analysis, enabling the identification of 2,895 high-confidence S-acylated proteins in human prostate cancer cells.

bioRxiv · Mar 26, 2019Biochemistry

Optimization of DNA extraction from human urinary samples for mycobiome community profiling

A. L. Ackerman, J. T. Anger, M. U. Khalique, J. E. Ackerman, J. Tang, J. Kim, D. M. Underhill, M. R. Freeman, Multidisciplinary Approach to the Study of Pelvic Pain (MAPP)

This paper optimizes DNA extraction from human urine to better profile both bacterial and fungal communities using next-generation sequencing.

bioRxiv · Dec 21, 2018Microbiology