SNTA1 GeneRescues Ion Channel Function in Cardiomyocytes Derived from Induced Pluripotent Stem Cells Reprogrammed from Muscular Dystrophy Patients with Arrhythmias
J. Jalife, E. N. Jimenez-Vazquez, M. Arad, A. Macias, M. L. Vera-Pedrosa, F. M. Cruz, A. J. Cuttita, A. Monteiro da Rocha, T. J. Herron, D. Ponce-Balbuena, G. Guerrero-Serna, O. Binah, D. E. Michele
This study shows that iPSC-CMs from DMD patients with arrhythmias have NaV1.5-Kir2.1 channelosome dysfunction, which can be rescued by 1-syntrophin.
bioRxiv · Jan 25, 2022 · PreprintCell Biology