Author

G. P. van Wezel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 14

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 12 Approach:experimental assay· 12 Research Focus:host-pathogen & immune response· 6 Research Focus:cell type annotation· 5 Research Focus:cell signaling & trafficking· 2 Research Focus:clustering· 2 Research Focus:development & morphogenesis· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

C. Du· 4 shared D. Claessen· 4 shared A. BriegeliD· 3 shared D. E. Rozen· 2 shared D. van Dissel· 2 shared E. Tenconi· 2 shared J. Willemse· 2 shared L. T. van der Aart· 2 shared

Activity by Year

2017-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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4 shared papersMicrobiology

C. Du

Mutual co-authors in cluster

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14 papers

Recent·Most cited

CslA and GlxA from Streptomyces lividans form a functional cellulose synthase complex

X. Zhong, S. Nicolardi, R. Ouyang, M. Wuhrer, C. Du, G. P. van Wezel, E. Vijgenboom, A. Briegel, D. Claessen

This paper shows that CslA and GlxA from Streptomyces lividans form a functional cellulose synthase complex capable of synthesizing cellulose in vitro.

bioRxiv · Nov 20, 2023 · PreprintMicrobiology

Systems-wide analysis of the ROK-family regulatory gene rokL6 and its role in the control of glucosamine toxicity in Streptomyces coelicolor

C. Li, M. Urem, C. Du, L. Zhang, G. P. van Wezel

The paper identifies RokL6 as a regulator that controls the expression of the MFS transporter SCO1448, which protects Streptomyces coelicolor from glucosamine toxicity by exporting toxic metabolites.

bioRxiv · Sep 20, 2023 · PreprintMicrobiology

New from old: discovery of the novel antibiotic actinomycin L in Streptomyces sp. MBT27

N. Machushynets, S. S. Elsayed, C. Du, M. A. Siegler, M. de la Cruz, O. Genilloud, T. Hankemeier, G. P. van Wezel

This paper discovers novel actinomycin derivatives, L1 and L2, produced by Streptomyces sp. MBT27 through metabolic analysis and molecular networking, showing their unique biosynthesis involving two metabolic pathways.

bioRxiv · Oct 12, 2021 · PreprintMicrobiology

Competition sensing alters antibiotic production in Streptomyces

S. Westhoff, A. Kloosterman, S. F. A. van Hoesel, G. P. van Wezel, D. E. Rozen

This study shows that Streptomyces produce antibiotics more when competing with closely related strains or those sharing biosynthetic pathways, but not when threatened by toxins, and often reduce production under resource limitation.

mBio · Feb 23, 2021Peer-reviewedMicrobiology

Branching of sporogenic aerial hyphae in sflA and sflB mutants of Streptomyces coelicolor correlates to ectopic localization of DivIVA and FtsZ in time and space

L. Zhang, J. Willemse, P. Yague, E. de Waal, D. Claessen, G. P. van Wezel

This study shows that SflA and SflB mutants of Streptomyces coelicolor exhibit hyphal branching and ectopic DivIVA/FtsZ localization during sporulation.

bioRxiv · Dec 26, 2020 · PreprintMicrobiology

Teichoic acids anchor distinct cell wall lamellae in an apically growing bacterium

E. Ultee, L. T. van der Aart, D. van Dissel, C. Diebolder, G. P. van Wezel, D. Claessen, A. Briegel

This study uses cryo-electron tomography to show that teichoic acids anchor distinct cell wall lamellae in the apically growing bacterium Streptomyces coelicolor.

Communications Biology · Jun 17, 2020Peer-reviewedMicrobiology

Integration of machine learning and pan-genomics expands the biosynthetic landscape of RiPP natural products

A. M. Kloosterman, P. Cimermancic, S. S. Elsayed, C. Du, M. Hadjithomas, M. S. Donia, M. A. Fischbach, G. P. van Wezel, M. H. Medema

The paper introduces decRiPPter, a machine learning and pan-genomic approach to discover novel RiPP classes, identifying 42 new candidate families from Streptomyces genomes.

bioRxiv · May 19, 2020Microbiology

Bagremycin Antibiotics and Ferroverdin iron-chelators are synthetized by the Same Gene Cluster

L. Martinet, A. Naome, B. Deflandre, M. Maciejewska, D. Tellatin, E. Tenconi, N. Smargiasso, E. De Pauw, G. P. van Wezel, S. Rigali

The paper shows that ferroverdins and bagremycins, two metabolites with different bioactivities, are produced from the same BGC, with their formation depending on iron availability.

bioRxiv · May 8, 2019 · PreprintMicrobiology

Discovery of Novel Glycerolated Quinazolinones from Streptomyces sp. MBT27

G. P. van Wezel, N. Machushynets, C. Wu, S. Elsayed, T. Hankemeier

This study identifies novel glycerolated quinazolinones produced by Streptomyces sp. MBT27 under glycerol-induced conditions and elucidates their biosynthetic pathway.

bioRxiv · Dec 27, 2018Microbiology

Spatial structure increases the benefits of antibiotic production in Streptomyces griseus

S. Westhoff, S. B. Otto, A. Swinkels, B. Bode, G. P. van Wezel, D. E. Rozen

This study shows that spatial structure enhances the fitness benefits of streptomycin production in S. griseus by reducing invasion thresholds and enabling competition against susceptible strains.

bioRxiv · Nov 29, 2018Microbiology

Production of glycine-derived ammonia as a low-cost and long-distance antibiotic strategy by Streptomyces

M. Avalos, P. Garbeva, J. M. Raaijmakers, G. P. van Wezel

The paper shows streptomycetes produce ammonia from glycine to kill bacteria over long distances, enhancing their antibiotics' effectiveness.

bioRxiv · Oct 24, 2018Microbiology

Structural and proteomic changes in viable but non-culturable Vibrio cholerae

S. Brenzinger, L. T. van der Aart, G. P. van Wezel, J.-M. Lacroix, T. Glatter, A. Briegel

This study investigates structural and proteomic changes in Vibrio cholerae during the viable but non-culturable state using electron cryo-tomography and proteomic analysis.

bioRxiv · Oct 2, 2018Microbiology

Prodiginine Production in Streptomyces coelicolor Correlates Temporally and Spatially to Programmed Cell Death

E. Tenconi, M. Traxler, C. Hoebreck, G. P. van Wezel, S. Rigali

This study shows that prodiginine production in Streptomyces coelicolor correlates with programmed cell death, suggesting self-toxic metabolites drive PCD during morphogenesis.

bioRxiv · Jan 19, 2018Microbiology

SParticle, an algorithm for the analysis of filamentous microorganisms in submerged cultures

J. Willemse, F. Buke, D. van Dissel, S. Grevink, D. Claessen, G. P. van Wezel

SParticle analyzes filamentous microorganism morphology in submerged cultures using automated image analysis and is available as an ImageJ plugin.

bioRxiv · Jul 4, 2017Microbiology