Author

D. El-Nachef

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:scRNA-seq· 2 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1

Frequent Co-Authors

C. E. Murry· 4 shared A. M. Martinson· 2 shared J. Davis· 2 shared K. M. Beussman· 2 shared N. J. Sniadecki· 2 shared W. R. MacLellan· 2 shared X. Yang· 2 shared A. Bertero· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersCell Biology

C. E. Murry

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4 papers

Recent·Most cited

Pharmacologic Therapy for Engraftment Arrhythmia Induced by Transplantation of Human Cardiomyocytes

K. Nakamura, L. E. Neidig, X. Yang, G. J. Weber, D. El-nachef, H. Tsuchida, S. Dupras, F. A. Kalucki, A. Jayabalu, A. Futakuchi-Tsuchida, D. S. Nakamura, S. Marchiano, A. Bertero, M. R. Robinson, K. Cain, , C. E. Murry

This study shows that amiodarone and ivabradine together prevent cardiac death and reduce arrhythmia burden in a porcine model of engraftment arrhythmia after human cardiomyocyte transplantation.

Stem Cell Reports · Oct 1, 2021Peer-reviewedPharmacology & Toxicology

A Rainbow Reporter Tracks Single Cells and Reveals Heterogeneous Cellular Dynamics among Pluripotent Stem Cells and their Differentiated Derivatives

D. El-Nachef, K. Shi, K. M. Beussman, R. Martinez, M. C. Regier, G. W. Everett, C. E. Murry, K. R. Stevens, J. E. Young, N. J. Sniadecki, J. Davis

This paper introduces a rainbow reporter system for tracking single cell dynamics in pluripotent stem cells and their derivatives, revealing heterogeneous behaviors during clonal expansion and differentiation.

bioRxiv · Jan 8, 2020Cell Biology

High-Resolution 3D Fluorescent Imaging of Intact Tissues

D. El-Nachef, A. M. Martinson, X. Yang, C. E. Murry, W. R. MacLellan

This paper describes an optimized method for high-resolution 3D fluorescent imaging of human and rodent tissues, achieving sub-micron resolution and imaging depth over 100 micrometers.

bioRxiv · Nov 26, 2019 · PreprintCell Biology

Engrafted Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Undergo Clonal Expansion In Vivo

D. El-Nachef, D. Bugg, K. M. Beussman, A. M. Martinson, C. E. Murry, N. J. Sniadecki, J. Davis

The paper uses a fluorescent barcoding system to track clonal expansion of engrafted hPSC-CMs in vivo, finding that some cells proliferate while others hypertrophy without dividing.

bioRxiv · Nov 20, 2019Cell Biology