R. Martinez

Identification of pharmacological inducers of a reversible hypometabolic state for whole organ preservation

The paper identifies SNC80 as a drug that reversibly slows metabolism in Xenopus and demonstrates its cross-species applicability in human organs-on-chips and porcine organs.

Recovery mode: Marine protected areas enhance the resilience of kelp species from marine heatwaves

This study shows marine protected areas enhance recovery of some invertebrate species after marine heatwaves but not others, with benefits depending on species traits.

Extracellular vesicles produced during fungal infection in humans are immunologically active

This study identifies and characterizes extracellular vesicles from human fungal infections, showing their role in modulating host immune responses through metabolite-mediated polarization of macrophages.

Patient phenotypes and their relation to TNFα signaling and immune cell composition in critical illness and autoimmune disease

The paper identifies a hyper-inflammatory phenotype linked to TNF signaling and mature neutrophils in critical illness and autoimmune disease using machine learning and patient data.

Stricturing Crohn's disease single-cell RNA sequencing reveals fibroblast heterogeneity and intercellular interactions

This study uses single-cell RNA sequencing to analyze fibroblast heterogeneity and interactions in Crohn's disease strictures, identifying CDH11 as a potential therapeutic target.

Differential expression analysis of sexual and apomictic Boechera uncovers FAS4 as crucial for gametogenesis

This study identifies FAS4 as crucial for gametogenesis by comparing sexual and apomictic Boechera reproductive tissues through RNA-Seq.

mTOR inhibition enhances delivery and activity of antisense oligonucleotides in uveal melanoma cells

This study shows that mTOR inhibition improves the delivery and effectiveness of antisense oligonucleotides in uveal melanoma cells and other cell types.

Phytochemical Nrf2 activator attenuates skeletal muscle mitochondrial dysfunction and impaired proteostasis in a preclinical model of musculoskeletal aging

This study shows that a Nrf2 activator improves mitochondrial function and proteostasis in aging guinea pigs but does not significantly enhance mobility.

Pharmacologic inhibition of Protein Kinase C α and Protein Kinase C β halts renal function decline indirectly, by blunting hyperphagia, and directly reduces adiposity in the ZSF1 rat model of type 2 diabetes

The paper evaluates a PKC inhibitor in a T2D rat model, finding it halts renal decline indirectly via reduced hyperphagia and directly lowers adiposity.

A Rainbow Reporter Tracks Single Cells and Reveals Heterogeneous Cellular Dynamics among Pluripotent Stem Cells and their Differentiated Derivatives

This paper introduces a rainbow reporter system for tracking single cell dynamics in pluripotent stem cells and their derivatives, revealing heterogeneous behaviors during clonal expansion and differentiation.

Depletion of the AD risk gene SORL1 selectively impairs neuronal endosomal traffic independent of amyloidogenic APP processing

This study shows that SORL1 depletion in neurons causes endosome enlargement, a key AD hallmark, without affecting amyloidogenic APP processing.

The genomic landscape of intrinsic and acquired resistance to cyclin-dependent kinase 4/6 inhibitors in patients with hormone receptor positive metastatic breast cancer

The paper identifies eight resistance mechanisms to CDK4/6 inhibitors in HR+ breast cancer, present in 80% of resistant tumors, with potential therapeutic strategies.

Galectin-3 inhibits Paracoccidioides brasiliensis growth and impacts paracoccidioidomycosis through multiple mechanisms

This study shows Galectin-3 inhibits Paracoccidioides brasiliensis growth and affects extracellular vesicle stability, suggesting a direct antimicrobial role in paracoccidioidomycosis.