K. Cain

Efficient overexpression and purification of SARS-CoV-2 Nucleocapsid proteins in Escherichia coli

The paper describes the scalable production and purification of SARS-CoV-2 nucleocapsid proteins in E. coli and evaluates their use in ELISA assays.

The antipsychotic medications aripiprazole, brexpiprazole and cariprazine are off-target respiratory chain complex I inhibitors

This study shows that antipsychotics aripiprazole, brexpiprazole, and cariprazine inhibit mitochondrial respiratory complex I, causing toxicity and movement disorders.

Metabolic reprogramming provides a novel approach to overcome resistance to BH3-mimetics in Malignant Pleural Mesothelioma

This study identifies metabolic reprogramming as a strategy to overcome resistance to BH3-mimetics in MPM by combining glycolytic inhibition with MCL-1 and BCL-2/BCL-XL targeting.

Characterisation of FADD interactome reveals novel insights into FADD recruitment and signalling at the Death Inducing Signalling Complex (DISC)

This study identifies novel FADD interactors that modulate FADD recruitment to the DISC and downstream apoptotic signaling.

Pharmacologic Therapy for Engraftment Arrhythmia Induced by Transplantation of Human Cardiomyocytes

This study shows that amiodarone and ivabradine together prevent cardiac death and reduce arrhythmia burden in a porcine model of engraftment arrhythmia after human cardiomyocyte transplantation.