N. J. Sniadecki

Cold temperature induces a TRPM8-independent calcium release from the endoplasmic reticulum in human platelets

This study shows cold temperature activates human platelets via TRPM8-dependent and -independent mechanisms, with TRPM8 involved in early activation and ER calcium release driving later responses.

Correcting dilated cardiomyopathy with fibroblast-targeted p38 deficiency

This study shows that targeting p38 in cardiac fibroblasts can reverse fibrosis and improve cardiomyocyte function in a mouse model of dilated cardiomyopathy.

Perpendicular Shear Stresses Drive Transmural Helical Remodeling in Engineered Human Ventricular Models

This study shows that perpendicular shear stress drives helical transmural remodeling in engineered human ventricles, revealing how physical forces influence cardiac architecture.

The nucleus bypasses obstacles by deforming like a drop with surface tension mediated by lamin A/C

The paper shows lamin A/C enables nuclear deformation through fibrous environments by acting like surface tension, allowing nuclei to bypass obstacles without rupturing.

Disc and Actin-Associated Protein 1 Influence Attachment in the Intestinal Parasite Giardia lamblia

This study investigates the role of GlActin and DAAP1 in Giardia lamblia's ventral disc function and attachment, finding that DAAP1 depletion impairs attachment despite intact discs.

Black Dots: Microcontact-Printed, Reference-Free Traction Force Microscopy

This paper introduces a traction force microscopy technique called 'black dots' to measure cellular forces without constraining cell shape, finding that higher force correlates with increased spread area, circularity, and F-actin uniformity in platelets.

Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein granules within processing bodies

This study investigates how RBM20 mutations affect splicing and ribonucleoprotein granules in cardiomyopathy, revealing distinct pathogenic mechanisms between missense and knockout mutations.

The Giardia lamellipodium-like ventrolateral flange supports attachment and rapid cytokinesis

This paper identifies Flangin, an actin-associated protein essential for forming the ventrolateral flange (VLF) in Giardia, which supports attachment and rapid cytokinesis.

SARS-CoV-2 infects human pluripotent stem cell-derived cardiomyocytes, impairing electrical and mechanical function

This study shows SARS-CoV-2 infects human pluripotent stem cell-derived cardiomyocytes, causing electrical and mechanical dysfunction in cardiac cells.

A Rainbow Reporter Tracks Single Cells and Reveals Heterogeneous Cellular Dynamics among Pluripotent Stem Cells and their Differentiated Derivatives

This paper introduces a rainbow reporter system for tracking single cell dynamics in pluripotent stem cells and their derivatives, revealing heterogeneous behaviors during clonal expansion and differentiation.

Engrafted Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Undergo Clonal Expansion In Vivo

The paper uses a fluorescent barcoding system to track clonal expansion of engrafted hPSC-CMs in vivo, finding that some cells proliferate while others hypertrophy without dividing.

Functional Maturation of Human iPSC-based Cardiac Microphysiological Systems with Tunable Electroconductive Decellularized Extracellular Matrices

This study develops tunable electroconductive hydrogels to enhance maturation of hiPSC-derived cardiac tissues, showing improved contractile and electrophysiological function and drug response.