Pervasive promoter hypermethylation of silenced TERT alleles in human cancers
D. Esopi, M. K. Graham, J. A. Brosnan-Cashman, J. Meyers, A. Vaghasia, A. Gupta, B. Kumar, M. C. Haffner, C. M. Heaphy, A. M. De Marzo, A. K. Meeker, W. Nelson, S. J. Wheelan, S. Yegnasubramanian
The paper investigates TERT promoter methylation in cancer cells and finds that hypermethylation represses TERT expression, explaining modest telomerase activation in most cancers.
bioRxiv · Jan 29, 2020Cancer Biology