Author

A. K. Meeker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Pathology· 2

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

C. M. Heaphy· 5 shared A. M. De Marzo· 2 shared C. Davis· 2 shared J. A. Brosnan-Cashman· 2 shared M. K. Graham· 2 shared S. Yegnasubramanian· 2 shared A. Gupta· 1 shared A. Vaghasia· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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5 shared papersCancer Biology

C. M. Heaphy

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5 papers

Recent·Most cited

Chromogenic detection of telomere lengths in situ aids the identification of precancerous lesions in the prostate

O. Ertunc, E. Smearman, Q. Zheng, J. L. Hicks, J. A. Brosnan-Cashman, T. Jones, C. Gomes-Alexandre, L. Trabzonlu, A. K. Meeker, A. M. De Marzo, C. M. Heaphy

This paper introduces a chromogenic in situ hybridization method to measure telomere lengths in prostate tissues, aiding in the identification of precancerous lesions.

bioRxiv · Apr 4, 2023Pathology

The TERT promoter is polycomb-repressed in neuroblastoma cells with long telomeres

M. K. Graham, B. Xu, C. Davis, A. K. Meeker, C. M. Heaphy, S. Yegnasubramanian, M. A. Dyer, M. Zeineldin

This study shows that TERT promoter hypomethylation and chromatin state differ in neuroblastoma based on telomere maintenance mechanisms, with repressive marks in long telomere-associated cells.

bioRxiv · May 18, 2022Cancer Biology

Therapeutic vulnerability to ATR inhibition in concurrent NF1 and ATRX-deficient high-grade solid tumors

M. Yuan, C. G. Eberhart, C. A. Pratilas, J. O. Blakeley, C. Davis, M. Stojanova, K. Reilly, A. K. Meeker, C. M. Heaphy, F. J. Rodriguez

This study shows that combining NF1 and ATRX deficiency makes certain solid tumors vulnerable to ATR inhibition, especially those with alternative lengthening of telomeres.

bioRxiv · Feb 3, 2022 · PreprintCancer Biology

Photochemical pre-bleaching of formalin-fixed archival prostate tissues significantly reduces autofluorescence to facilitate multiplex immunofluorescence staining

A. K. Meeker, C. M. Heaphy, C. M. Davis, S. Roy, E. A. Platz

This paper shows that photochemical pre-bleaching reduces autofluorescence in archival prostate tissues, improving multiplex immunofluorescence signal-to-noise.

bioRxiv · Nov 9, 2021 · PreprintPathology

Pervasive promoter hypermethylation of silenced TERT alleles in human cancers

D. Esopi, M. K. Graham, J. A. Brosnan-Cashman, J. Meyers, A. Vaghasia, A. Gupta, B. Kumar, M. C. Haffner, C. M. Heaphy, A. M. De Marzo, A. K. Meeker, W. Nelson, S. J. Wheelan, S. Yegnasubramanian

The paper investigates TERT promoter methylation in cancer cells and finds that hypermethylation represses TERT expression, explaining modest telomerase activation in most cancers.

bioRxiv · Jan 29, 2020Cancer Biology