Author

M. K. Graham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

S. Yegnasubramanian· 4 shared A. Gupta· 3 shared A. M. De Marzo· 3 shared J. Meyers· 3 shared W. Nelson· 3 shared A. K. Meeker· 2 shared A. Skaist· 2 shared A. Vaghasia· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersCancer Biology

S. Yegnasubramanian

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Author profile →

4 papers

Recent·Most cited

Convergent alterations in the tumor microenvironment of MYC-driven human and murine prostate cancer

M. K. Graham, R. Wang, R. Chikarmane, B. Wodu, A. Vaghasia, A. Gupta, Q. Zheng, J. Hicks, P. Sysa-Shah, X. Pan, N. Castagna, J. Liu, J. Meyers, A. Skaist, Y. Zhang, , S. Yegnasubramanian

This study identifies MYC signaling activation as a common driver of tumor microenvironment alterations in human and murine prostate cancer through single-cell RNA-sequencing and comparative analysis.

bioRxiv · Sep 7, 2023Cancer Biology

The TERT promoter is polycomb-repressed in neuroblastoma cells with long telomeres

M. K. Graham, B. Xu, C. Davis, A. K. Meeker, C. M. Heaphy, S. Yegnasubramanian, M. A. Dyer, M. Zeineldin

This study shows that TERT promoter hypomethylation and chromatin state differ in neuroblastoma based on telomere maintenance mechanisms, with repressive marks in long telomere-associated cells.

bioRxiv · May 18, 2022Cancer Biology

Single-cell atlas of epithelial and stromal cell heterogeneity by lobe and strain in the mouse prostate

M. K. Graham, R. Chikarmane, R. Wang, A. M. Vaghasia, A. Gupta, Q. Zheng, B. P. Wodu, X. Pan, N. Castagna, J. Liu, J. Meyers, A. Skaist, S. J. Wheelan, B. W. Simons, C. Bieberich, , S. Yegnasubramanian

The paper constructs a single-cell atlas of mouse prostate cell types across strains and lobes, revealing strain- and lobe-specific transcriptomic differences in epithelial cells and strain-lobespecific fibroblast subtypes.

bioRxiv · Jan 31, 2022Cell Biology

Pervasive promoter hypermethylation of silenced TERT alleles in human cancers

D. Esopi, M. K. Graham, J. A. Brosnan-Cashman, J. Meyers, A. Vaghasia, A. Gupta, B. Kumar, M. C. Haffner, C. M. Heaphy, A. M. De Marzo, A. K. Meeker, W. Nelson, S. J. Wheelan, S. Yegnasubramanian

The paper investigates TERT promoter methylation in cancer cells and finds that hypermethylation represses TERT expression, explaining modest telomerase activation in most cancers.

bioRxiv · Jan 29, 2020Cancer Biology