Author

D. F. Tough

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Coffin· 1 shared A. Patel· 1 shared A. Shillings· 1 shared A. Y. F. Li Yim· 1 shared B. Soskic· 1 shared C. E. Blunt· 1 shared C. G. C. Larminie· 1 shared D. A. Zwijnenburg· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperImmunology

A. Coffin

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140

M. Ghiboub, J. Koster, P. D. Craggs, A. Y. F. Li Yim, A. Shillings, S. Hutchinson, R. P. Bingham, K. Gatfield, I. L. Hageman, G. Yao, H. P. O'Keefe, A. Coffin, A. Patel, L. A. Sloan, D. J. Mitchell, , W. J. de Jonge

This study identifies SP140 as a druggable epigenetic reader and therapeutic target for Crohn's disease by showing that its inhibition reduces inflammatory macrophage activation and cytokine expression.

bioRxiv · Aug 10, 2020Immunology

Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines

E. C. Gamez, B. Soskic, T. I. Roumeliotis, E. So, D. J. Smyth, M. Baldrighi, D. Wille, N. Nakic, J. Esparza-Gordillo, C. G. C. Larminie, P. G. Bronson, D. F. Tough, W. C. Rowan, J. S. Choudhary, G. Trynka

The paper uses single-cell RNA-seq and other methods to show that CD4+ T cells form an effectorness gradient, with cytokine responses varying along this continuum.

bioRxiv · Sep 4, 2019Immunology