Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines
E. C. Gamez, B. Soskic, T. I. Roumeliotis, E. So, D. J. Smyth, M. Baldrighi, D. Wille, N. Nakic, J. Esparza-Gordillo, C. G. C. Larminie, P. G. Bronson, D. F. Tough, W. C. Rowan, J. S. Choudhary, G. Trynka
The paper uses single-cell RNA-seq and other methods to show that CD4+ T cells form an effectorness gradient, with cytokine responses varying along this continuum.
bioRxiv · Sep 4, 2019Immunology