Author

D. F. Tschaharganeh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

B. Bosbach· 1 shared C. S. Tran· 1 shared C.-C. Chen· 1 shared D. Requena· 1 shared E. R. Kastenhuber· 1 shared F. Kuehnel· 1 shared F. W. R. Vondran· 1 shared G. Ahlen· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

B. Bosbach

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2 papers

Recent·Most cited

Phosphatidylinositol 4-kinase III alpha governs cytoskeletal organization for invasiveness of liver cancer cells

C. S. Tran, J. Kersten, M. Breinig, J. Yan, T. Poth, O. Colasanti, T. Riedl, S. Faure-Dupuy, S. Diehl, L. Verhoye, T.-F. Li, M. Lingemann, P. Schult, G. Ahlen, L. Frelin, , V. Lohmann

This study identifies PI4KIII's role in promoting liver cancer invasiveness through cytoskeletal reorganization via PIK3C2γ and Akt2/paxillin-cofilin signaling.

bioRxiv · May 22, 2023Cell Biology

DNAJB1-PRKACA fusion kinase interacts with β-catenin and liver regenerative response to drive fibrolamellar hepatocellular carcinoma

E. R. Kastenhuber, G. Lalazar, D. F. Tschaharganeh, S. L. Houlihan, T. Baslan, C.-C. Chen, D. Requena, S. Tian, B. Bosbach, J. E. Wilkinson, S. M. Simon, S. W. Lowe

This study shows that the DNAJB1-PRKACA fusion kinase drives fibrolamellar hepatocellular carcinoma in mice and identifies β-catenin activation and environmental factors as contributors to tumor progression.

Proceedings of the National Academy of Sciences · Nov 21, 2017Peer-reviewedCancer Biology