Author

D. G. Amoako

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Evolutionary Biology· 1 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

A. M. Somboro· 3 shared H. M. Kumalo· 3 shared J. Osei Sekyere· 2 shared R. Khan· 2 shared A. De Klerk· 1 shared A. Djiyou· 1 shared A. G. Lucaci· 1 shared A. J. Greaney· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersMicrobiology

A. M. Somboro

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Enable, Empower, Succeed: Harnessing Open Science for Antimicrobial Resistance Containment

L. L. Founou, O. U. Lawal, A. Djiyou, E. E. Odih, D. G. Amoako, S. Fadanka, M. K. Aworh, S. Lukhele, D. Nikolic, A. Matimba, R. C. Founou

This paper describes a three-day bioinformatics workshop in Cameroon aimed at building local capacity for AMR genomics surveillance using web-based tools.

bioRxiv · Feb 20, 2024 · PreprintScientific Communication & Education

Molecular mechanisms underlying Warburgia salutaris effects on oxidative stress and apoptotic parameters in Human Hepatoma Cells

A. M. Somboro, D. G. Amoako, H. M. Kumalo, R. M. Khan

This study investigates the molecular effects of Warburgia salutaris on oxidative stress and apoptosis in HepG2 cells, finding it induces oxidative stress and promotes apoptosis, suggesting potential anti-cancer properties.

bioRxiv · Mar 5, 2022 · PreprintBiochemistry

Selection analysis identifies unusual clustered mutational changes in Omicron lineage BA.1 that likely impact Spike function

D. P. Martin, S. Lytras, A. G. Lucaci, W. Maier, B. Gruning, S. D. Shank, S. Weaver, O. S. MacLean, R. J. Orton, P. Lemey, M. F. Boni, H. Tegally, G. W. Harkins, C. Scheepers, J. N. Bhiman, , S. L. Kosakovsky Pond

The paper identifies 13 rare mutations in the Omicron S-gene that cluster in functionally important regions and likely impact Spike function, suggesting cooperative interactions that mitigate fitness costs.

bioRxiv · Jan 14, 2022 · PreprintEvolutionary Biology

Evaluation of 1, 4, 7-Triazacyclononane (TACN) as a potential Metallo-B-Lactamase inhibitor in Enterobacteriaceae: Restoring the Activity of B-lactams

A. M. Somboro, D. G. Amoako, J. Osei Sekyere, H. M. Kumalo, R. Khan, L. Bester, S. Essack

This study evaluates TACN as a potential MBL inhibitor, showing it restores carbapenem activity against CREs and demonstrates efficient inhibition with low cytotoxicity.

bioRxiv · Sep 6, 2018Microbiology

In Vitro Potentiation of Carbapenems with Tannic Acid Against Carbapenemase Producing Enterobacteriaceae: Exploring Natural Products as Potential Carbapenemase Inhibitors

A. M. Somboro, J. OSEI SEKYERE, D. G. Amoako, H. M. Kumalo, R. Khan, L. A. Bester, S. Y. Essack

This study shows tannic acid can reduce carbapenem resistance in Enterobacteriaceae by inhibiting carbapenemases, with stronger effects on metallo-β-lactamases than serine-β-lactamases.

bioRxiv · Jul 10, 2018Microbiology