Author

J. N. Bhiman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:statistical model· 1 Research Focus:variant effect prediction· 1 Organism:virus· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A. von Gottberg· 2 shared B. E. Lambson· 2 shared P. Kgagudi· 2 shared P. L. Moore· 2 shared T. de Oliveira· 2 shared A. De Klerk· 1 shared A. G. Lucaci· 1 shared A. J. Greaney· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersEvolutionary Biology

A. von Gottberg

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Author profile →

3 papers

Recent·Most cited

Novavax NVX-COV2373 triggers potent neutralization of Omicron sub-lineages

J. N. Bhiman, S. I. Richardson, B. E. Lambson, P. Kgagudi, N. Mzindle, H. Kaldine, C. Crowther, G. Gray, L.-G. Bekker, A. Koen, L. Fairlie, L. Fouche, Q. Bhorat, K. Dheda, M. Tameris, , P. L. Moore

This study evaluates the neutralizing antibody response to NVX-CoV2373 against Omicron sub-lineages after two or three doses, showing improved neutralization with a third dose.

bioRxiv · Jul 14, 2022 · PreprintImmunology

Selection analysis identifies unusual clustered mutational changes in Omicron lineage BA.1 that likely impact Spike function

D. P. Martin, S. Lytras, A. G. Lucaci, W. Maier, B. Gruning, S. D. Shank, S. Weaver, O. S. MacLean, R. J. Orton, P. Lemey, M. F. Boni, H. Tegally, G. W. Harkins, C. Scheepers, J. N. Bhiman, , S. L. Kosakovsky Pond

The paper identifies 13 rare mutations in the Omicron S-gene that cluster in functionally important regions and likely impact Spike function, suggesting cooperative interactions that mitigate fitness costs.

bioRxiv · Jan 14, 2022 · PreprintEvolutionary Biology

SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma

C. K. Wibmer, F. Ayres, T. Hermanus, M. Madzivhandila, P. Kgagudi, B. Oosthuysen, B. E. Lambson, T. de Oliveira, M. Vermeulen, K. van den Berg, T. Rossouw, M. Boswell, V. Ueckermann, S. Meiring, A. von Gottberg, , P. L. Moore

This study shows that SARS-CoV-2 501Y.V2 pseudovirus escapes neutralization by South African convalescent plasma but not binding, suggesting potential for reinfection and reduced vaccine efficacy.

bioRxiv · Jan 18, 2021Immunology