Author

A. De Klerk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Organism:virus· 2 Approach:comparative / phylogenetic analysis· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

D. L. Robertson· 2 shared S. L. Kosakovsky Pond· 2 shared S. Lytras· 2 shared A. G. Lucaci· 1 shared A. Henrickson· 1 shared A. J. Greaney· 1 shared A. Nekrutenko· 1 shared A. Sigal· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersEvolutionary Biology

D. L. Robertson

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Author profile →

3 papers

Recent·Most cited

Investigating RNA-RNA interactions through computational and biophysical analysis

T. Mrozowich, S. M. Park, M. Waldl, A. Henrickson, S. Tersteeg, C. R. Nelson, A. De Klerk, B. Demeler, I. L. Hofacker, M. T. Wolfinger, T. R. Patel

This paper computationally predicts and biophysically validates long-range RNA-RNA interactions in JEV, showing the cyclization sequence drives interaction with nM affinity.

bioRxiv · Feb 1, 2022 · PreprintBiochemistry

Selection analysis identifies unusual clustered mutational changes in Omicron lineage BA.1 that likely impact Spike function

D. P. Martin, S. Lytras, A. G. Lucaci, W. Maier, B. Gruning, S. D. Shank, S. Weaver, O. S. MacLean, R. J. Orton, P. Lemey, M. F. Boni, H. Tegally, G. W. Harkins, C. Scheepers, J. N. Bhiman, , S. L. Kosakovsky Pond

The paper identifies 13 rare mutations in the Omicron S-gene that cluster in functionally important regions and likely impact Spike function, suggesting cooperative interactions that mitigate fitness costs.

bioRxiv · Jan 14, 2022 · PreprintEvolutionary Biology

Exploring the natural origins of SARS-CoV-2 in the light of recombination

S. Lytras, J. Hughes, D. Martin, A. de Klerk, R. Lourens, S. L. Kosakovsky Pond, W. Xia, X. Jiang, D. L. Robertson

This paper traces the origins of SARS-CoV-2 to horseshoe bats in China and Southeast Asia, identifies recombination events in Sarbecoviruses, and highlights the need for more wildlife sampling to understand zoonotic spillover risks.

bioRxiv · Jan 22, 2021Evolutionary Biology