Author

R. J. Orton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Evolutionary Biology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:whole-genome sequencing· 3 Approach:statistical model· 2 Organism:virus· 2 Approach:comparative / phylogenetic analysis· 1 Research Focus:drug response / drug discovery· 1 Research Focus:ecology & biodiversity· 1 Approach:experimental assay· 1 Research Focus:genome assembly· 1

Frequent Co-Authors

A. da Silva Filipe· 2 shared A. Kohl· 2 shared A. De Klerk· 1 shared A. G. Lucaci· 1 shared A. H. Patel· 1 shared A. J. Greaney· 1 shared A. M. Szemiel· 1 shared A. Merits· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

A. da Silva Filipe

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Selection analysis identifies unusual clustered mutational changes in Omicron lineage BA.1 that likely impact Spike function

D. P. Martin, S. Lytras, A. G. Lucaci, W. Maier, B. Gruning, S. D. Shank, S. Weaver, O. S. MacLean, R. J. Orton, P. Lemey, M. F. Boni, H. Tegally, G. W. Harkins, C. Scheepers, J. N. Bhiman, , S. L. Kosakovsky Pond

The paper identifies 13 rare mutations in the Omicron S-gene that cluster in functionally important regions and likely impact Spike function, suggesting cooperative interactions that mitigate fitness costs.

bioRxiv · Jan 14, 2022 · PreprintEvolutionary Biology

In vitro evolution of Remdesivir resistance reveals genome plasticity of SARS-CoV-2

A. M. Szemiel, A. Merits, R. J. Orton, O. MacLean, A. Wickenhagen, G. Lieber, R. M. Pinto, M. L. Turnbull, S. Wang, D. Mair, A. da Silva Filipe, B. J. Willett, S. J. Wilson, A. H. Patel, E. C. Thomson, , M. E. Stewart

This study shows that in vitro evolution of SARS-CoV-2 under remdesivir selects for resistant mutations, but these mutations do not spread widely in global variants.

bioRxiv · Feb 1, 2021Microbiology

Population genomics of louping ill virus provide new insights into the evolution of tick-borne flaviviruses

J. J. Clark, J. Gilray, R. J. Orton, M. Baird, G. S. Wilkie, A. da Silva Filipe, N. Johnson, C. J. McInnes, A. Kohl, R. Biek

This study sequences 22 louping ill virus isolates to analyze genomic diversity and evolutionary history, finding low diversity, limited positive selection, and challenges in estimating molecular clock rates for tick-borne flaviviruses.

bioRxiv · Feb 14, 2020Evolutionary Biology

Spatiotemporal dynamics of RNA virus diversity in a phyllosphere microbial community

L. M. Bono, R. J. Orton, E. L. Peredo, H. G. Morrison, M. J. Sistrom, S. Simmons, P. Turner

The paper examines spatiotemporal dynamics of RNA virus diversity in white clover patches, finding consistent dominance of Alphaflexiviridae and WClMV across space and time.

bioRxiv · Sep 18, 2019 · PreprintMicrobiology