Author

D. Hanna

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Benos· 1 shared A. Berg· 1 shared A. Diacon· 1 shared A. Grenell· 1 shared A. Lenaerts· 1 shared B. Anand-Apte· 1 shared C. Singh· 1 shared D. Deshpande· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperBiochemistry

A. Benos

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Novel tuberculosis combination regimens of two and three-months therapy duration

T. Gumbo, M. Chapagain, G. Magombedze, S. Srivastava, D. Deshpande, J. G. Pasipanodya, R. Gumbo, K. Dheda, A. Diacon, D. J. Hermann, D. Hanna

The paper predicts four pan-tuberculosis regimens that could cure tuberculosis in 2-3 months using mathematical modeling and pharmacokinetics/pharmacodynamic analysis of drug combinations.

bioRxiv · Mar 13, 2022 · PreprintPharmacology & Toxicology

Model-Based Meta-Analysis of Relapsing Mouse Model Studies from the Critical Path to Tuberculosis Drug Regimens Initiative Database

A. Berg, J. Clary, D. Hanna, E. Nuermberger, A. Lenaerts, N. Ammerman, M. E. Ramey, D. Hartley, D. Hermann

The paper performs a model-based meta-analysis of relapsing mouse model studies to compare TB drug regimen efficacy across multiple studies.

bioRxiv · Sep 13, 2021Pharmacology & Toxicology

The urea cycle is transcriptionally controlled by hypoxia-inducible factors

C. Singh, A. Benos, A. Grenell, V. Tran, D. Hanna, N. Kannekanti, B. Anand-Apte, H. Brunengraber, J. Sears

The paper shows that HIFs regulate urea cycle genes CPS1 and ARG1, leading to increased urea cycle activity in the liver under hypoxia.

bioRxiv · Jan 25, 2021 · PreprintBiochemistry