The urea cycle is transcriptionally controlled by hypoxia-inducible factors
C. Singh, A. Benos, A. Grenell, V. Tran, D. Hanna, N. Kannekanti, B. Anand-Apte, H. Brunengraber, J. Sears
Abstract
Here, we demonstrate transcriptional regulation of urea cycle genes CPS1 and ARG1 by hypoxia-inducible factors (HIFs) and demonstrate a hepatic HIF dependent increase in urea cycle activity.
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