Author

H. Brunengraber

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Abbas· 2 shared A. Vaziri-Gohar· 2 shared H. J. Graor· 2 shared I. Bederman· 2 shared J. J. Hue· 2 shared J. M. Salvino· 2 shared J. M. Winter· 2 shared J. R. Brody· 2 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

A. Abbas

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Increased glucose availability sensitizes pancreatic cancer to chemotherapy

A. Vaziri-Gohar, J. J. Hue, H. J. Graor, A. Abbas, M. Zarei, O. Hajihassani, G. Titomihelakis, J. Feczko, M. Rathore, R. Wang, M. Zarei, M. Goudarzi, R. Zhang, B. Willard, L. Zhang, , J. M. Winter

This study shows that high glucose levels increase the effectiveness of chemotherapy in pancreatic cancer by reducing glutathione biosynthesis, which enhances oxidative stress in cancer cells.

bioRxiv · Apr 29, 2022Cancer Biology

The urea cycle is transcriptionally controlled by hypoxia-inducible factors

C. Singh, A. Benos, A. Grenell, V. Tran, D. Hanna, N. Kannekanti, B. Anand-Apte, H. Brunengraber, J. Sears

The paper shows that HIFs regulate urea cycle genes CPS1 and ARG1, leading to increased urea cycle activity in the liver under hypoxia.

bioRxiv · Jan 25, 2021 · PreprintBiochemistry

Cancer cells are sensitive to wild-type IDH1 inhibition under nutrient limitation

A. Vaziri-Gohar, J. J. Hue, H. J. Graor, E. Prendergast, V. Chen, J. Cassel, F. S. Mohammed, A. Abbas, K. Dukleska, I. Khokhar, O. Hajhassani, M. Zarei, R. Wang, L. D. Rothermel, I. Bederman, , J. M. Winter

This study shows that wild-type IDH1 is a metabolic target in pancreatic cancer cells under nutrient limitation, and FDA-approved drugs can inhibit it effectively in preclinical models.

bioRxiv · Nov 19, 2020 · PreprintCancer Biology