Author

D. J. Benton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:virus· 1

Frequent Co-Authors

D. Joshi· 2 shared A. Borg· 1 shared A. G. Wrobel· 1 shared A. M. Gonzalez-Ramirez· 1 shared A. Marchesi· 1 shared B. Schumann· 1 shared C. Roustan· 1 shared D. Oxley· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

D. Joshi

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A cyclic peptide toolkit reveals mechanistic principles of peptidylarginine deiminase IV (PADI4) regulation

M. T. Bertran, R. Walmsley, T. F. M. Cummings, I. Aramburu, D. J. Benton, J. Assalaarachchi, M. Chasampalioti, T. Swanton, D. Joshi, S. Federico, H. Okkenhaug, L. Yu, D. Oxley, S. Walker, V. Papayannopoulos, , L. J. Walport

The paper develops cyclic peptide modulators of PADI4 and reveals their mechanism of action and cellular activity.

bioRxiv · Dec 12, 2023Biochemistry

O-Linked Sialoglycans Modulate the Proteolysis of SARS-CoV-2 Spike and Likely Contribute to the Mutational Trajectory in Variants of Concern

E. Gonzalez-Rodriguez, M. Zol-Hanlon, G. Bineva-Todd, A. Marchesi, M. Skehel, K. Mahoney, C. Roustan, A. Borg, L. Di Vagno, S. Kjaer, A. G. Wrobel, D. J. Benton, P. Nawrath, S. L. Flitsch, D. Joshi, , B. Schumann

This paper shows that O-linked sialoglycans affect SARS-CoV-2 spike proteolysis by furin and TMPRSS2, and may drive mutations in variants of concern.

bioRxiv · Sep 15, 2022Cell Biology

Genetic determinants of receptor-binding preference and zoonotic potential of H9N2 avian influenza viruses

T. P. Peacock, J. E. Sealy, W. T. Harvey, D. J. Benton, R. Reeve, M. Iqbal

This study identifies genetic mutations in H9N2 influenza viruses that influence their receptor-binding preferences and zoonotic potential by altering their affinity for human-like or avian receptors.

Journal of Virology · Feb 10, 2021Peer-reviewedMicrobiology