Author

J. E. Sealy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 7 Organism:chicken / avian· 5 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Research Focus:variant calling· 1 Organism:virus· 1

Frequent Co-Authors

M. Iqbal· 7 shared J.-R. Sadeyen· 6 shared P. Chang· 4 shared S. Bhat· 4 shared H. Shelton· 3 shared T. P. Peacock· 3 shared A. L. Clements· 2 shared B. Mollett· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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7 shared papersMicrobiology

M. Iqbal

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Investigation of H9N2 avian influenza immune escape mutant that lacks haemagglutination activity

T. K. Karunarathna, J.-R. Sadeyen, S. Bhat, P. Chang, J. Yang, M. Qureshi, J. E. Sealy, R. Daines, M. Iqbal

This paper identifies an H9N2 avian influenza virus mutant with a G149E mutation in HA that loses haemagglutination activity but retains replication fitness, highlighting challenges for vaccine and surveillance efforts.

bioRxiv · Oct 3, 2023 · PreprintMicrobiology

Antigenic characterisation of human monoclonal antibodies for therapeutic use against H7N9 avian influenza virus

P. Chang, D. Lukosaityte, J. E. Sealy, P. Rijal, J.-R. Sadeyen, S. Bhat, S. Crossley, R. Daines, K.-Y. A. Huang, A. Townsend, M. Iqbal

This study characterizes human monoclonal antibodies against H7N9 avian influenza virus, identifies key epitopes, and evaluates escape mutants' impact on viral fitness and immune evasion.

bioRxiv · Sep 16, 2022 · PreprintMicrobiology

The origin of internal genes contributes to the replication and transmission fitness of H7N9 avian influenza virus

J. James, S. Bhat, S. K. Walsh, H. M. T. K. Karunarathna, J.-R. Sadeyen, P. Chang, J. E. Sealy, S. Mahmood, B. Mollett, M. J. Slomka, S. M. Brookes, M. Iqbal

This study shows that internal gene segments from different H9N2 lineages affect the replication and transmission fitness of H7N9 avian influenza viruses in chickens and their zoonotic potential.

bioRxiv · Aug 17, 2022Microbiology

Co-infection of chickens with H9N2 and H7N9 avian influenza viruses leads to emergence of reassortant H9N9 virus with increased fitness for poultry and enhanced zoonotic potential

S. Bhat, J. James, J.-R. Sadeyen, S. Mahmood, H. Heverest, P. Chang, S. Walsh, A. M. Byrne, B. Mollett, F. Lean, J. E. Sealy, H. Shelton, M. J. Slomka, S. M. Brookes, M. Iqbal

bioRxiv · Apr 5, 2021Microbiology

Genetic determinants of receptor-binding preference and zoonotic potential of H9N2 avian influenza viruses

T. P. Peacock, J. E. Sealy, W. T. Harvey, D. J. Benton, R. Reeve, M. Iqbal

This study identifies genetic mutations in H9N2 influenza viruses that influence their receptor-binding preferences and zoonotic potential by altering their affinity for human-like or avian receptors.

Journal of Virology · Feb 10, 2021Peer-reviewedMicrobiology

Contribution of segment 3 to the acquisition of virulence in contemporary H9N2 avian influenza viruses

A. L. Clements, J. E. Sealy, T. P. Peacock, J.-R. Sadeyen, S. Hussain, S. J. Lycett, H. Shelton, P. Digard, M. Iqbal

This paper identifies a single amino acid change in the PA protein of H9N2 avian influenza viruses that enhances virulence and replication in poultry.

bioRxiv · May 27, 2020Microbiology

PA-X is an avian virulence factor in H9N2 avian influenza virus

A. L. Clements, T. P. Peacock, J. E. Sealy, S. Hussain, J.-R. Sadeyen, H. Shelton, P. Digard, M. Iqbal

This study investigates the role of PA-X in H9N2 avian influenza viruses, finding it enhances replication in mammalian cells and contributes to virulence in chickens.

bioRxiv · May 25, 2020Microbiology