Author

G. Bineva-Todd

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

B. Canal· 2 shared C. T. Lim· 2 shared D. Joshi· 2 shared F. Weissmann· 2 shared J. F. Diffley· 2 shared J. Milligan· 2 shared K. Labib· 2 shared K. W. Tan· 2 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

B. Canal

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

O-Linked Sialoglycans Modulate the Proteolysis of SARS-CoV-2 Spike and Likely Contribute to the Mutational Trajectory in Variants of Concern

E. Gonzalez-Rodriguez, M. Zol-Hanlon, G. Bineva-Todd, A. Marchesi, M. Skehel, K. Mahoney, C. Roustan, A. Borg, L. Di Vagno, S. Kjaer, A. G. Wrobel, D. J. Benton, P. Nawrath, S. L. Flitsch, D. Joshi, , B. Schumann

This paper shows that O-linked sialoglycans affect SARS-CoV-2 spike proteolysis by furin and TMPRSS2, and may drive mutations in variants of concern.

bioRxiv · Sep 15, 2022Cell Biology

Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of nsp5 Main Protease

C. Basier, R. Beale, G. Bineva-Todd, B. Canal, J. F. Curran, T. D. Deegan, J. F. Diffley, R. Fujisawa, M. Howell, D. Joshi, K. Labib, C. T. Lim, J. Milligan, H. Nagaraj, N. O'Reilly, , T. U. Zeisner

This study identifies small molecule inhibitors of SARS-CoV-2 nsp5 main protease, finding calpain inhibitor I and peptidyl fluoromethylketones with potent antiviral activity.

bioRxiv · Apr 7, 2021Biochemistry

Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp3 Papain-like Protease

L. A. Armstrong, R. Beale, G. Bineva-Todd, B. Canal, J. F. Diffley, L. S. Drury, M. Howell, Y. Kulathu, K. Labib, C. T. Lim, J. Milligan, N. O'Reilly, E. Ozono, K. W. Tan, R. Ulferts, , J. Zeng

This study identifies two small molecule inhibitors of SARS-CoV-2 Nsp3 PLpro that inhibit viral replication in cell culture.

bioRxiv · Apr 7, 2021Biochemistry