Author

D. J. Dickinson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:C. elegans· 6 Research Focus:cell signaling & trafficking· 5 Assay:proteomics· 5 Research Focus:cell type annotation· 3 Research Focus:development & morphogenesis· 2 Assay:electronic health records· 1 Assay:imaging· 1

Frequent Co-Authors

L. N. Deutz· 2 shared Y. Chang· 2 shared A. Akhmanova· 1 shared A. Brooks· 1 shared A. G. Gubieda· 1 shared A. J. M. Wollman· 1 shared A. M. Pani· 1 shared B. Goldstein· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCell Biology

L. N. Deutz

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Author profile →

8 papers

Recent·Most cited

KLP-19 controls microtubule length in the spindle midzone of C. elegans, affecting spindle dynamics and force transmission during mitosis.

V. Zimyanin, M. M. Magaj, N. I. Manzi, C.-H. Yu, T. V. Gibney, Y.-Z. Chen, B. Mustafa, X. Horton, K. Siller, A. M. Pani, D. Needleman, D. J. Dickinson, S. Redemann

The paper identifies KLP-19's role in regulating microtubule length in the C. elegans spindle midzone, impacting spindle dynamics and force transmission during mitosis.

Journal of Cell Science · Aug 15, 2026Peer-reviewedCell Biology

Atypical Protein Kinase C Promotes its own Asymmetric Localisation by Phosphorylating Cdc42 in Polarising Cells

J. Packer, A. G. Gubieda, A. Brooks, L. N. Deutz, I. Squires, S. Ellison, C. Schneider, S. R. Naganathan, A. J. M. Wollman, D. J. Dickinson, J. Rodriguez

This paper shows that aPKC phosphorylates Cdc42 to regulate its own asymmetric localization and cell polarity in C. elegans zygotes.

bioRxiv · Oct 27, 2023 · PreprintCell Biology

Membrane extraction in native lipid nanodiscs reveals dynamic regulation of Cdc42 complexes during cell polarization

L. N. Deutz, S. Sarikaya, D. J. Dickinson

The paper isolates membrane proteins from C. elegans zygotes into lipid nanodiscs to study Cdc42 complex dynamics during cell polarization, finding stronger Cdc42-aPKC/Par6 interactions during polarity maintenance.

bioRxiv · Jun 12, 2023Cell Biology

Efficient and rapid fluorescent protein knock-in with universal donors in mammalian stem cells

Y. Shi, N. Kopparapu, L. Ohler, D. J. Dickinson

This paper describes a method for efficiently inserting fluorescent proteins into endogenous genes in mammalian stem cells using NHEJ, reducing the time from transfection to imaging to less than two weeks.

bioRxiv · Oct 10, 2022 · PreprintCell Biology

Rapid extraction and kinetic analysis of protein complexes from single cells

S. Sarıkaya, D. J. Dickinson

This paper introduces a method to measure protein complex dissociation rates in single cells using time-resolved single-molecule analysis after optical cell lysis.

bioRxiv · Jul 7, 2021Biochemistry

A particle size threshold governs diffusion and segregation of PAR-3 during cell polarization

Y. Chang, D. J. Dickinson

The paper investigates how PAR-3 oligomer size affects its diffusion and segregation during cell polarization in C. elegans embryos, finding that trimers are essential while larger clusters are not.

bioRxiv · Jun 7, 2021Cell Biology

Snapshots of single particles from single cells using electron microscopy

X. Yi, E. J. Verbeke, Y. Chang, D. J. Dickinson, D. W. Taylor

This paper combines microfluidic single cell extraction with single particle electron microscopy to study protein complexes in C. elegans embryos, revealing ribosome structures and developmental dynamics.

bioRxiv · Oct 4, 2018Biochemistry

Optogenetic dissection of mitotic spindle positioning in vivo

L.-E. Fielmich, R. Schmidt, D. J. Dickinson, B. Goldstein, A. Akhmanova, S. van den Heuvel

This study uses optogenetics to dissect mitotic spindle positioning in C. elegans embryos, showing that G-GTP signaling is dispensable and LIN-5Mud/NuMA activates dynein-dependent forces.

bioRxiv · May 14, 2018Cell Biology