Author

D. J. Williamson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:fluorescence / live-cell microscopy· 4 Research Focus:clustering· 2 Approach:deep learning· 2 Organism:human· 2 Assay:imaging· 2 Approach:microscopy & imaging analysis· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

D. M. Owen· 3 shared J. Griffie· 3 shared S. Simoncelli· 2 shared A. Caceres· 1 shared A. M. Szalai· 1 shared A. P. Cope· 1 shared B. Siarry· 1 shared C. Bray· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersBiophysics

D. M. Owen

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Author profile →

5 papers

Recent·Most cited

Live Cell Multicolour Lifetime Imaging Using Genetically Encodable Fluorophores

T. Starling, I. Carlon-Andres, M. Iliopoulou, D. J. Williamson, S. Padilla-Parra

The paper demonstrates simultaneous imaging of nine fluorescent proteins using FLIM and PIE, and introduces a method to unmix spectrally similar FPs pixel-by-pixel.

bioRxiv · Oct 6, 2022 · PreprintBiophysics

Correction of multiple-blinking artefacts in photoactivated localisation microscopy

L. G. Jensen, T. Y. Hoh, D. J. Williamson, J. Griffie, D. Sage, P. Rubin-Delanchy, D. M. Owen

This paper corrects multiple-blinking artefacts in PALM data using model-based clustering and calibration-free blinking dynamics estimation, enabling accurate quantification of fluorophore clustering.

bioRxiv · Mar 24, 2021 · PreprintBiophysics

Three-dimensional total-internal reflection fluorescence nanoscopy with nanometric axial resolution by photometric localization of single molecules

A. M. Szalai, B. Siarry, J. Lukin, D. J. Williamson, N. Unsain, D. Refojo, A. Caceres, M. Pilo-Pais, G. Acuna, D. M. Owen, S. Simoncelli, F. D. Stefani

This paper introduces SIMPLER, a method to achieve nanometric axial resolution in 3D single-molecule localization microscopy without hardware changes to TIRF microscopes.

bioRxiv · Apr 17, 2020Biophysics

Multi-colour DNA-qPAINT reveals how Csk nano-clusters regulate T-cell receptor signalling

S. Simoncelli, j. Griffie, D. J. Williamson, J. Bibby, C. Bray, R. Zamoyska, A. P. Cope, D. Owen

The paper uses DNA-qPAINT to study Csk nano-clusters in T-cells, finding they regulate signaling by re-recruiting after stimulation and interacting with PTPN22.

bioRxiv · Nov 27, 2019 · PreprintImmunology

Machine-learning for cluster analysis of localization microscopy data.

D. J. Williamson, G. L. Burn, J. Griffie, D. M. Davis, D. M. Owen

The paper develops a supervised machine-learning approach to cluster analysis of localization microscopy data, demonstrating its effectiveness on simulated and experimental datasets.

bioRxiv · Dec 25, 2018Cell Biology