S. Harper

T-cell receptor structures and predictive models reveal comparable alpha and beta chain structural diversity despite differing genetic complexity

The paper evaluates TCR structure prediction models using a large dataset, finds comparable structural diversity in alpha and beta chains, and provides over 1.5M predicted structures for further analysis.

Protection against Clostridioides difficile disease by a naturally avirulent C. difficile strain

This paper shows that an avirulent C. difficile strain, ST1-75, protects mice from virulent strain-induced colitis by outcompeting it through rapid amino acid depletion, suggesting potential as a biotherapeutic for CDI prevention.

Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis

Tuning the potency and therapeutic window of ImmTAC molecules by affinity modulation

This paper investigates how altering affinity for target and CD3 affects the potency and specificity of ImmTAC molecules, finding that optimal activation occurs with strong TCR affinity and intermediate anti-CD3 affinity.

Stem cell quiescence requires PRC2/PRC1-mediated mitochondrial checkpoint

The paper shows that PRC2/PRC1-mediated mitochondrial checkpoint regulates quiescence in Drosophila GSCs and human iPSCs through mitophagy and mitochondrial dynamics.

Janus effect of glucocorticoids on differentiation of muscle fibro/adipogenic progenitors

This study identifies glucocorticoids as both inhibitors and promoters of muscle fibro/adipogenic progenitor differentiation, revealing their dual role in muscle homeostasis.

Prioritisation of oncology therapeutic targets using CRISPR-Cas9 screening

This study uses CRISPR-Cas9 screens in cancer cell lines to identify and prioritize new oncology therapeutic targets based on gene fitness, biomarkers, and tractability.