L. Coughlan

Immunity to seasonal coronavirus spike proteins does not protect from SARS-CoV-2 challenge in a mouse model but has no detrimental effect on protection mediated by COVID-19 mRNA vaccination

This study investigates whether immunity to seasonal coronavirus spike proteins protects against SARS-CoV-2 in mice and affects mRNA vaccine efficacy, finding no increased protection but no detrimental effect on vaccination.

Trivalent NDV-HXP-S vaccine protects against phylogenetically distant SARS-CoV-2 variants of concern in mice

The paper tests a trivalent NDV-HXP-S vaccine against SARS-CoV-2 variants in mice, showing increased protection and cross-neutralizing antibodies against Omicron.

Vaccination with B.1.1.7, B.1.351 and P.1 variants protects mice from challenge with wild type SARS-CoV-2

This study evaluates cross-neutralizing antibody responses and protective efficacy of vaccines based on SARS-CoV-2 variants B.1.1.7, B.1.351, and P.1 in mice against wild type SARS-CoV-2 challenge.

A Newcastle disease virus-vector expressing a prefusion-stabilized spike protein of SARS-CoV-2 induces protective immune responses against prototype virus and variants of concern in mice and hamsters

This study develops a Newcastle disease virus-based vaccine expressing a prefusion-stabilized SARS-CoV-2 spike protein, showing strong immune responses and cross-neutralization against variants in mice and hamsters.

Murine monoclonal antibodies against RBD of SARS-CoV-2 neutralize authentic wild type SARS-CoV-2 as well as B.1.1.7 and B.1.351 viruses and protect in vivo in a mouse model in a neutralization dependent manner

This study evaluates murine monoclonal antibodies against SARS-CoV-2 RBD, showing neutralization of wild-type and variants, and in vivo protection dependent on neutralization.

A public broadly neutralizing antibody class targets a membrane-proximal anchor epitope of influenza virus hemagglutinin

This study identifies a class of broadly neutralizing antibodies targeting a conserved membrane-proximal epitope on influenza HA, showing their induction by a chimeric HA vaccine.

Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Modified Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine

This paper demonstrates that a novel TLR7/8 agonist adjuvant enables single-shot protection against SARS-CoV-2 and influenza in mice using recombinant spike protein and inactivated vaccines.

Introduction of two prolines and removal of the polybasic cleavage site leads to optimal efficacy of a recombinant spike based SARS-CoV-2 vaccine in the mouse model

This study shows that deleting the polybasic cleavage site and introducing proline mutations in the SARS-CoV-2 spike protein enhances vaccine efficacy in a mouse model.

Comparison of Transgenic and Adenovirus hACE2 Mouse Models for SARS-CoV-2 Infection

This study compares two SARS-CoV-2 infection models in mice: K18-hACE2 transgenic and adenovirus-mediated hACE2 delivery, showing differences in viral replication and disease outcomes.

Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions.

The paper investigates receptor interactions of HAdV-D26/48 fiber-knob protein, finding low affinity for CAR and no evidence of interaction with CD46 or Desmoglein 2.