Author

C. A. Aguilar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 8 Bioengineering· 2 Immunology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 13 Organism:mouse· 11 Research Focus:development & morphogenesis· 7 Research Focus:cell type annotation· 6 Research Focus:cancer & tumor microenvironment· 5 Research Focus:cell signaling & trafficking· 4 Assay:bulk RNA-seq· 3 Research Focus:cell-cell communication· 3

Frequent Co-Authors

B. A. Yang· 6 shared S. V. Brooks· 6 shared J. A. Larouche· 5 shared C. Davis· 4 shared J. A. Castor-Macias· 4 shared J. F. Markworth· 4 shared L. A. Brown· 4 shared P. M. Fraczek· 4 shared

Activity by Year

2019-2024 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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6 shared papersCell Biology

B. A. Yang

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Author profile →

13 papers

Recent·Most cited

Quantification of local matrix deposition during muscle stem cell activation using engineered hydrogels

P. Duran, B. A. Yang, E. Plaster, M. Eiken, C. Loebel, C. A. Aguilar

This study quantifies matrix deposition by muscle stem cells during activation using engineered hydrogels and shows it is critical for maintaining stem cell function.

bioRxiv · Jan 20, 2024 · PreprintBioengineering

Manipulation of the nucleoscaffold potentiates cellular reprogramming kinetics

B. A. Yang, A. Monteiro da Rocha, I. Newton, A. Shcherbina, S.-W. Wong, P. M. Fraczek, J. A. Larouche, H. L. Hiraki, B. M. Baker, J.-W. Shin, S. Takayama, M. D. Thouless, C. A. Aguilar

This study shows that manipulating Lamin A/C affects nuclear structure and reprogramming efficiency in human fibroblasts.

bioRxiv · Mar 12, 2023Cell Biology

Maresin 1 Repletion Improves Muscle Regeneration After Volumetric Muscle Loss

J. A. Castor-Macias, J. A. Larouche, E. C. Wallace, B. D. Spence, A. Eames, B. A. Yang, C. Davis, S. V. Brooks, K. R. Maddipati, J. F. Markworth, C. A. Aguilar

This study shows that Maresin 1 treatment reduces fibrosis and improves muscle regeneration after volumetric muscle loss by modulating inflammation.

bioRxiv · Nov 19, 2022Physiology

Three-dimensional chromatin re-organization during muscle stem cell aging

B. A. Yang, J. A. Larouche, K. M. Sabin, P. M. Fraczek, S. C. J. Parker, C. A. Aguilar

This study examines how 3D chromatin organization changes in muscle stem cells during aging, revealing static global structures and rewired local contacts linked to transcription factor binding and gene expression changes.

bioRxiv · Sep 21, 2022Cell Biology

Spatiotemporal mapping of immune and stem cell dysregulation after volumetric muscle loss

J. A. Larouche, E. C. Wallace, B. D. Spence, S. A. Johnson, M. Kulkarni, E. Buras, B. N. Brown, S. F. Badylak, C. A. Aguilar

This study identifies a pro-fibrotic immune-progenitor cell interaction in VML that impairs muscle regeneration, showing conservation across mouse and canine models.

bioRxiv · Jun 3, 2022Cell Biology

Neutrophil and natural killer cell imbalances prevent muscle stem cell mediated regeneration following murine volumetric muscle loss

J. A. Larouche, S. J. Kurpiers, B. A. Yang, C. Davis, P. M. Fraczek, M. Hall, S. V. Brooks, L. D. Shea, C. A. Aguilar

The study compares muscle injuries leading to regeneration or fibrosis, revealing that neutrophil-natural killer cell communication affects muscle stem cell repair.

bioRxiv · Jul 2, 2021Cell Biology

Sestrins regulate age-induced deterioration of muscle stem cell homeostasis

B. A. Yang, J. A. Castor-Macias, P. M. Fraczek, L. A. Brown, M. Kim, S. V. Brooks, J. H. Lee, C. A. Aguilar

This study shows that Sestrins maintain muscle stem cell quiescence and function by regulating mTORC1 signaling and metabolism, and their loss accelerates age-related deterioration.

bioRxiv · Dec 15, 2020Cell Biology

Lipidomic Profiling Reveals an Age-Related Deficiency of Skeletal Muscle Proresolving Mediators that Contributes to Maladaptive Tissue Remodeling

J. F. Markworth, L. A. Brown, E. Lim, J. A. Castor-Macias, J. Larouche, P. C. D. Macpherson, C. Davis, C. A. Aguilar, K. R. Maddipati, S. V. Brooks

This study identifies age-related deficiencies in proresolving mediators in skeletal muscle, leading to impaired regeneration and inflammation, and shows that RvD1 treatment can mitigate some adverse effects.

bioRxiv · Nov 5, 2020Immunology

Immunoresolvents Support Skeletal Myofiber Regeneration via Actions on Myeloid and Muscle Stem Cells

J. F. Markworth, L. A. Brown, E. Lim, C. Floyd, J. Larouche, J. A. Castor-Macias, K. B. Sugg, D. C. Sarver, P. C. F. Macpherson, C. Davis, C. A. Aguilar, K. R. Maddipati, S. V. Brooks

This study shows that resolvin D1 promotes skeletal muscle regeneration by modulating myeloid cells and muscle stem cells, improving recovery without directly affecting myogenesis.

bioRxiv · Jun 12, 2020Immunology

Single Cell Deconstruction of Muscle Stem Cell Heterogeneity During Aging Reveals Sensitivity to the Neuromuscular Junction

P. J. Ulintz, J. Larouche, M. Mohiuddin, J. Castor Macias, S. J. Kurpiers, W. Liu, J. J. Choi, L. A. Brown, J. F. Markworth, K. de Silva, B. D. Levi, S. D. Merajver, J. V. Chakkalakal, Y. C. Jang, S. V. Brooks, C. A. Aguilar

The paper identifies a neuro-responsive subset of muscle stem cells that support neuromuscular junction integrity during aging and neurodegeneration.

bioRxiv · May 28, 2020Cell Biology

Regenerating motor neurons prime muscle stem cells for myogenesis by enhancing protein synthesis and mitochondrial bioenergetics

J. J. Choi, E. J. Shin, W. M. Han, S. E. Anderson, M. Mohiuddin, N. H. Lee, T. Tran, S. Nakhai, H. Jeong, A. Shcherbina, G. Jeong, D. G. Oh, L. Weinstock, S. B. Sankar, M. E. Ogle, , Y. C. Jang

This study shows that motor neurons enhance muscle stem cell function by boosting protein synthesis and mitochondrial activity, which is critical for muscle regeneration and is disrupted in diseases like muscular dystrophy and aging.

bioRxiv · May 24, 2020 · PreprintCell Biology

Transplantation of muscle stem cell mitochondria rejuvenates the bioenergetic function of dystrophic muscle

M. Mohiuddin, J. J. Choi, N. H. Lee, H. H. Jeong, S. E. Anderson, W. M. Han, B. Aliya, T. Z. Peykova, S. Verma, A. J. Garcia, C. A. Aguilar, Y. C. Jang

This study shows that transplanting healthy muscle stem cells into dystrophic muscle improves mitochondrial function and bioenergetics, while compromised stem cells fail to do so.

bioRxiv · Apr 17, 2020 · PreprintCell Biology

Pre-Innervated Tissue Engineered Muscle Promotes a Pro-Regenerative Microenvironment Following Volumetric Muscle Loss

S. DAS, K. D. BROWNE, F. A. LAIMO, J. C. MAGGIORE, H. Kaisaier, C. A. Aguilar, Z. S. ALI, F. MOURKIOTI, D. K. CULLEN

This study develops pre-innervated tissue engineered muscle constructs to enhance regeneration after volumetric muscle loss in rats.

bioRxiv · Nov 13, 2019Bioengineering